⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11600094 | 0.72 | — | — | |
| SCHEMBL9711600 | 0.70 | — | — | |
| SCHEMBL356893 | 0.70 | — | — | |
| SCHEMBL1037721 | 0.69 | — | — | |
| SCHEMBL3980860 | 0.69 | — | — | |
| SCHEMBL162495 | 0.68 | — | — | |
| SCHEMBL1983188 | 0.68 | — | — | |
| SCHEMBL1536249 | 0.68 | — | — | |
| SCHEMBL1088381 | 0.68 | — | — | |
| SCHEMBL3277518 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7829566-B2 | Such as (7-chloro-2-styryl-quinazolin-4-yl)-(3-imidazol-1-yl-propyl)-amine; glycoprotein antagonist; anticholesterol agents; cardiovascular disorders; strokes; antiischemic agents | MEDERSKI WERNER | 2010-11-09 | — | — | US | disclosed |
| US-7547702-B2 | 4-amino-quinazolines | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2009-06-16 | — | — | US | disclosed |
| US-20070293667-A1 | 4-Amino-quinazolines | MEDERSKI WERNER | 2007-12-20 | — | — | US | disclosed |
| US-7060706-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2006-06-13 | — | — | US | disclosed |
| US-20060019974-A1 | Glycoprotein antagonist; anticholesterol agents; cardiovascular disorders; strokes; antiischemic agents | ORTHO-MCNEIL PHARMACEUTICALS, INC. | 2006-01-26 | — | — | US | disclosed |
| US-6890930-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |
| WO-2004030672-A1 | USE OF 4 AMINO-QUINAZOLINES AS ANTI CANCER AGENTS | MERCK PATENT GMBH (DE) | 2004-04-15 | — | — | WO | disclosed |
| WO-2004030671-A2 | USE OF 4-AMINO-QUINAZOLINES AS ANTI CANCER AGENTS | MERCK PATENT GMBH (DE) | 2004-04-15 | — | — | WO | disclosed |
| US-20040044204-A1 | 4-amino-quinazolines | ORTHO-MCNEIL PHARMACEUTICALS, INC. | 2004-03-04 | — | — | US | disclosed |
| EP-1318984-A1 | 4-AMINO-QUINAZOLINES | MERCK PATENT GmbH (DE) | 2003-06-18 | — | — | EP | disclosed |
| WO-2001023365-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |
| WO-2001023364-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |
| US-6180645-B1 | ANTIEPILEPIC AGENT | BOEHRINGER INGELHEIM GMBH (DE) | 2001-01-30 | — | — | US | disclosed |
| EP-0736012-B1 | ANELLATED DIHYDROPYRIDINES AND THEIR USE IN THE PRODUCTION OF PHARMACEUTICAL PREPARATIONS | BOEHRINGER INGELHEIM PHARMA (DE) | 2000-11-22 | — | — | EP | disclosed |
| US-5925650-A | PROTECTION AGAINST STROKE IN MAMMALS | BOEHRINGER INGELHEIM KG (DE) | 1999-07-20 | — | — | US | disclosed |
| US-5837712-A | PREVENTION OF STROKE | BOEHRINGER INGELHEIM KG (DE) | 1998-11-17 | — | — | US | disclosed |
| CN-1181379-A | Process for preparation of 3 -piperazinylbenzisothiazoles | SUMITOMO SEIKA CHEMICALS (JP) | 1998-05-13 | — | — | CN | disclosed |
| US-5607943-A | CARDIOPROTECTIVE, CEREBROPROTECTIVE, ANTIINFLAMMATORY AGENTS | BOEHRINGER INGELHEIM GMBH (DE) | 1997-03-04 | — | — | US | disclosed |
| EP-0736012-A1 | ANELLATED DIHYDROPYRIDINES AND THEIR USE IN THE PRODUCTION OF PHARMACEUTICAL PREPARATIONS | BOEHRINGER INGELHEIM KG (DE) | 1996-10-09 | — | — | EP | disclosed |
| WO-1995017388-A1 | ANELLATED DIHYDROPYRIDINES AND THEIR USE IN THE PRODUCTION OF PHARMACEUTICAL PREPARATIONS | BOEHRINGER INGELHEIM KG (DE) | 1995-06-29 | — | — | WO | disclosed |