Sugi Predict

Sugi Predict / Compounds / SCHEMBL3535697

SCHEMBL3535697

SCHEMBL3535697

Cn1c(-c2n[nH]c3ccc(Oc4cccnc4)cc23)nc2cc(C(F)(F)F)ccc21

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HTR2B P41595 1/20 0.41
▸ HTR6 P50406 1/20 0.41
▸ KIT P10721 4/20 0.40
▸ BRAF P15056 9/20 0.39
▸ CYP3A4 P08684 2/20 0.39
▸ PIM1 P11309 1/20 0.38
▸ MAP2K4 P45985 2/20 0.38
▸ RAF1 P04049 3/20 0.37
▸ KDR P35968 2/20 0.37
▸ STK25 O00506 1/20 0.37
▸ CIT O14578 1/20 0.37
▸ EPHB6 O15197 1/20 0.37
▸ MAP3K7 O43318 1/20 0.37
▸ RIPK2 O43353 1/20 0.37
▸ PAK3 O75914 1/20 0.37
▸ STK10 O94804 1/20 0.37
▸ MAP4K4 O95819 1/20 0.37
▸ ABL1 P00519 1/20 0.37
▸ LCK P06239 1/20 0.37
▸ FYN P06241 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3538588 0.91 MAP2K4 (0.39) KITBRAFCYP3A4MAP2K4RAF1
SCHEMBL3534151 0.89 BRAF (0.38) HTR2BHTR6KITBRAFCYP3A4
SCHEMBL3534652 0.88 BRAF (0.39) KITBRAFCYP3A4MAP2K4RAF1
SCHEMBL3539940 0.88 CACNA1D (0.42) HTR2BBRAFCYP3A4MAP2K4RAF1
SCHEMBL3536898 0.87 BRAF (0.41) KITBRAFCYP3A4MAP2K4RAF1
SCHEMBL3532970 0.87 CACNA1D (0.42) KITBRAFCYP3A4MAP2K4RAF1
SCHEMBL3535847 0.87 TRPV1 (0.42) KITBRAFCYP3A4MAP2K4RAF1
SCHEMBL3540348 0.87 BRAF (0.38) KITBRAFCYP3A4MAP2K4RAF1
SCHEMBL3538797 0.86 MAP2K4 (0.42) MAP2K4KDRFGFR1METAP2CYP11B1
SCHEMBL3538887 0.84 BRAF (0.37) KITBRAFCYP3A4MAP2K4RAF1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7642278-B2 Nitrogen compounds such as 3-(5-morpholin-4-yl-1H-benz-imidazol-2-yl)-1H-indazole and/or isomers, used as immunology modulators, antidiabetic agents, antiogenesis inhibitors or for prophylaxis of Alzheimer's disease NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) 2010-01-05 — — US disclosed
US-7642278-B2 Nitrogen compounds such as 3-(5-morpholin-4-yl-1H-benz-imidazol-2-yl)-1H-indazole and/or isomers, used as immunology modulators, antidiabetic agents, antiogenesis inhibitors or for prophylaxis of Alzheimer's disease NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) 2010-01-05 — — US disclosed
US-7642278-B2 Nitrogen compounds such as 3-(5-morpholin-4-yl-1H-benz-imidazol-2-yl)-1H-indazole and/or isomers, used as immunology modulators, antidiabetic agents, antiogenesis inhibitors or for prophylaxis of Alzheimer's disease NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) 2010-01-05 — — US disclosed
US-20060079564-A1 Indazole benzimidazole compounds CHIRON CORPORATION 2006-04-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060079564-A1 Indazole benzimidazole compounds ABL1, ABL2, ALK HTR2B 4224/4885HTR6 4286/4885KIT 1025/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.