Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.70 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.67 |
| ▸ | AURKA | O14965 | 3/20 | 0.67 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.60 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.59 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.58 |
| ▸ | CSF1R | P07333 | 3/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27758535 | 0.89 | AURKB (0.68) | EGFRAURKBAURKAINCENPRPS6KB1 | |
| Hydrochloric Acid SCHEMBL8810503 | 0.85 | AURKB (0.66) | EGFRAURKBAURKAINCENPRPS6KB1 | |
| SCHEMBL3530091 | 0.83 | EGFR (0.75) | EGFRAURKBAURKAIRAK4 | |
| SCHEMBL18996629 | 0.83 | EGFR (1.00) | EGFRAURKBMAPK14KDR | |
| SCHEMBL26784631 | 0.83 | AURKB (0.68) | EGFRAURKBAURKAINCENPRPS6KB1 | |
| Hydrochloric Acid SCHEMBL8808339 | 0.81 | AURKB (0.67) | EGFRAURKBAURKAINCENPRPS6KB1 | |
| SCHEMBL27758514 | 0.81 | FYN (0.70) | EGFRAURKBAURKAINCENPIRAK4 | |
| Anilinoquinazoline1 SCHEMBL1066538 | 0.81 | AURKB (1.00) | EGFRAURKBAURKAIRAK4MAPK14 | |
| Anilinoquinazoline1 SCHEMBL30195580 | 0.81 | AURKB (1.00) | EGFRAURKBAURKAIRAK4MAPK14 | |
| Anilinoquinazoline1 SCHEMBL3968007 | 0.80 | AURKB (0.98) | EGFRAURKBAURKAIRAK4MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709479-B1 | Quinazoline derivatives and their use as pharmaceuticals | ASTRAZENECA (SE) | 2010-05-04 | — | — | US | disclosed |
| EP-1218354-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021596-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |