Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 18/20 | 0.74 |
| ▸ | HSP90AB1 | P08238 | 18/20 | 0.74 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.66 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.66 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.66 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.66 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.66 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.66 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.66 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.66 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.66 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.66 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.66 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3127189 | 0.92 | HSP90AA1 (0.74) | HSP90AA1HSP90AB1HDAC3HDAC4HDAC1 | |
| SCHEMBL3532417 | 0.92 | HSP90AA1 (0.73) | HSP90AA1HSP90AB1HDAC3HDAC4HDAC1 | |
| SCHEMBL3125159 | 0.90 | HSP90AA1 (0.71) | HSP90AA1HSP90AB1HDAC3HDAC4HDAC1 | |
| SCHEMBL3118864 | 0.90 | HSP90AA1 (0.70) | HSP90AA1HSP90AB1HDAC3HDAC4HDAC1 | |
| SCHEMBL3113480 | 0.90 | HSP90AA1 (0.70) | HSP90AA1HSP90AB1HDAC3HDAC4HDAC1 | |
| SCHEMBL13703478 | 0.89 | HSP90AA1 (0.68) | HSP90AA1HSP90AB1HDAC3HDAC4HDAC1 | |
| SCHEMBL3126051 | 0.89 | HSP90AA1 (0.69) | HSP90AA1HSP90AB1HDAC3HDAC4HDAC1 | |
| SCHEMBL13703479 | 0.89 | HSP90AA1 (0.67) | HSP90AA1HSP90AB1HDAC3HDAC4HDAC1 | |
| SCHEMBL13703471 | 0.88 | HSP90AA1 (0.66) | HSP90AA1HSP90AB1HDAC3HDAC4HDAC1 | |
| SCHEMBL3518091 | 0.88 | HSP90AA1 (0.67) | HSP90AA1HSP90AB1HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100292255-A1 | Therapeutic Compounds and Their Use in Treating Diseases and Disorders | MYRIAD PHARMACEUTICALS, INC. (US) | 2010-11-18 | — | — | US | disclosed |
| US-20100292255-A1 | Therapeutic Compounds and Their Use in Treating Diseases and Disorders | MYRIAD PHARMACEUTICALS, INC. (US) | 2010-11-18 | — | — | US | disclosed |
| US-20100292255-A1 | Therapeutic Compounds and Their Use in Treating Diseases and Disorders | MYRIAD PHARMACEUTICALS, INC. (US) | 2010-11-18 | — | — | US | disclosed |
| EP-2219448-A1 | THERAPEUTIC COMPOUNDS AND THEIR USE IN TREATING DISEASES AND DISORDERS | Myriad Pharmaceuticals, Inc. (US) | 2010-08-25 | — | — | EP | disclosed |
| WO-2009065035-A1 | THERAPEUTIC COMPOUNDS AND THEIR USE IN TREATING DISEASES AND DISORDERS | MYRIAD GENETICS, INC. (US) | 2009-05-22 | — | — | WO | disclosed |
| WO-2009065035-A1 | THERAPEUTIC COMPOUNDS AND THEIR USE IN TREATING DISEASES AND DISORDERS | MYRIAD GENETICS, INC. (US) | 2009-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292255-A1 | Therapeutic Compounds and Their Use in Treating Diseases and Disorders | VHL, CLN6, CFTR | HSP90AA1 659/4885HSP90AB1 501/4885HDAC3 423/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.