⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4701756 | 0.98 | — | — | |
| Hydrochloric Acid SCHEMBL3963500 | 0.98 | — | — | |
| Water SCHEMBL28206229 | 0.98 | — | — | |
| Formic Acid SCHEMBL4699651 | 0.92 | — | — | |
| SCHEMBL193861 | 0.80 | — | — | |
| SCHEMBL28299873 | 0.79 | — | — | |
| Benzene SCHEMBL28096982 | 0.78 | — | — | |
| SCHEMBL30401460 | 0.78 | — | — | |
| Hydrochloric Acid SCHEMBL27969702 | 0.78 | — | — | |
| SCHEMBL28338918 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108069976-A | A kind of nitrogenous macrocyclic compounds, its preparation method, pharmaceutical composition and application | 山东罗欣药业集团股份有限公司 | 2018-05-25 | — | — | CN | claimed |
| CN-103732059-A | Nuclear hormone receptor modulators | ABBOTT LAB | 2014-04-16 | — | — | CN | claimed |
| CN-1511141-B | 10, 11-dihydro-10-hydroxy-5H-dibenzo [ b, f ] azepine-5-carboxamide and process for preparing 10, 11-dihydro-10-oxo-5H-dibenzo [ b, f ] azepine-5-carboxamide | PORTELA & CA SA | 2011-06-08 | — | — | CN | claimed |
| EP-1987037-A2 | FUSED HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2008-11-05 | — | — | EP | claimed |
| US-20080139807-A1 | Method For Preparation Of 10,11-Dihydro-10-Hydroxy-5H-Dibenz/B,F/Azepine-5-Carboxamide | PORTELA & C.A.,S.A. (DE) | 2008-06-12 | — | — | US | claimed |
| CN-101142191-A | Process for the preparation of 10,11-dihydro-10-hydroxy-5h-dibenz[b,f]azepine-5-carboxamide | PORTELA & CA SA (PT) | 2008-03-12 | — | — | CN | claimed |
| EP-1846376-A2 | METHOD FOR PREPARATION OF 10,11-DIHYDRO-10-HYDROXY-5H-DIBENZ/B,F/AZEPINE-5-CARBOXAMIDE | Portela & Ca., S.A. (PT) | 2007-10-24 | — | — | EP | claimed |
| WO-2007097470-A2 | FUSED NITROGEN- COMPRISING HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-08-30 | — | — | WO | claimed |
| WO-2006075925-A2 | METHOD FOR PREPARATION OF 10,11-DIHYDRO-10-HYDROXY-5H-DIBENZ/B,F/AZEPINE-5-CARBOXAMIDE | PORTELA & C.A., S.A. (PT) | 2006-07-20 | — | — | WO | claimed |
| EP-1680127-A1 | BENZAZEPINE DERIVATIVES AS MAO-B INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-07-19 | — | — | EP | claimed |
| CN-1759095-A | N,N'-substituted-1,3-diamino-2-hydroxypropane derivatives | ELAN PHARM INC (US) | 2006-04-12 | — | — | CN | claimed |
| WO-2005039591-A1 | BENZAZEPINE DERIVATIVES AS MAO-B INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-05-06 | — | — | WO | claimed |
| EP-1453789-A2 | N,N'-SUBSTITUTED-1,3-DIAMINO-2-HYDROXYPROPANE DERIVATIVES | Elan Pharmaceuticals, Inc. (US) | 2004-09-08 | — | — | EP | claimed |
| CN-1511141-A | 10, 11-dihydro-10-hydroxy-5H-dibenzo [ b, f ] azepine-5-carboxamide and process for preparing 10, 11-dihydro-10-oxo-5H-dibenzo [ b, f ] azepine-5-carboxamide | — | 2004-07-07 | — | — | CN | claimed |
| WO-2003040096-A2 | N, N'-SUBSTITUTED-1,3-DIAMINO-2-HYDROXYPROPANE DERIVATIVES | ELAN PHARMACEUTICALS, INC. (US) | 2003-05-15 | — | — | WO | claimed |
| EP-0192034-B1 | DIBENZAZEPINE DERIVATIVES, THEIR PREPARATION, STARTING MATERIALS FOR THEIR PREPARATION, AND USE OF THE DIBENZAZEPINE DERIVATIVES AS PESTICIDES | CIBA-GEIGY AG (CH) | 1992-07-15 | — | — | EP | claimed |
| EP-0108715-A1 | Dibenzazepine carboxamides | CIBA-GEIGY AG (CH) | 1984-05-16 | — | — | EP | claimed |
| CN-116981675-A | Degradation of Bruton's Tyrosine Kinase (BTK) by conjugation of BTK inhibitors to E3 ligase ligands and methods of use | 百济神州有限公司 | 2023-10-31 | — | — | CN | disclosed |
| WO-2005039591-A1 | BENZAZEPINE DERIVATIVES AS MAO-B INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-05-06 | — | — | WO | disclosed |
| CN-1511141-A | 10, 11-dihydro-10-hydroxy-5H-dibenzo [ b, f ] azepine-5-carboxamide and process for preparing 10, 11-dihydro-10-oxo-5H-dibenzo [ b, f ] azepine-5-carboxamide | — | 2004-07-07 | — | — | CN | disclosed |