Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 9/20 | 0.67 |
| ▸ | IGF1R | P08069 | 5/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | CDK1 | P06493 | 3/20 | 0.51 |
| ▸ | CDK4 | P11802 | 2/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | BTK | Q06187 | 1/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.50 |
| ▸ | JUN | P05412 | 1/20 | 0.50 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.49 |
| ▸ | IKBKB | O14920 | 1/20 | 0.49 |
| ▸ | CHUK | O15111 | 1/20 | 0.49 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3534358 | 0.89 | CDK2 (0.69) | CDK2IGF1RCDK1CDK4MAPK8 | |
| SCHEMBL3538116 | 0.88 | CDK2 (0.61) | CDK2IGF1RKCNH2CDK1CDK4 | |
| SCHEMBL4804777 | 0.88 | CDK2 (0.72) | CDK2IGF1RCDK1CDK4PLK4 | |
| SCHEMBL3542584 | 0.86 | CDK2 (0.59) | CDK2IGF1RKCNH2CDK1CDK4 | |
| SCHEMBL3542436 | 0.86 | CDK2 (0.65) | CDK2IGF1RCDK1CDK4MAPK8 | |
| SCHEMBL27658496 | 0.85 | CDK2 (0.73) | CDK2IGF1RCDK1CDK4PLK4 | |
| SCHEMBL7978513 | 0.83 | CDK2 (0.69) | CDK2IGF1RCDK1CDK4MAPK8 | |
| SCHEMBL1684872 | 0.83 | CDK2 (0.70) | CDK2IGF1RKCNH2CDK1CDK4 | |
| SCHEMBL4805850 | 0.83 | CDK2 (0.68) | CDK2IGF1RCDK1CDK4MAPK8 | |
| SCHEMBL3539933 | 0.82 | CDK2 (0.60) | CDK2IGF1RCDK1CDK4MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745428-B2 | Imidazo[1,2-A]pyridine having anti-cell-proliferation activity | ASTRAZENECA AB (SE) | 2010-06-29 | — | — | US | claimed |