Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.75 |
| ▸ | CTSD | P07339 | 6/20 | 0.71 |
| ▸ | BACE2 | Q9Y5Z0 | 6/20 | 0.71 |
| ▸ | REN | P00797 | 4/20 | 0.67 |
| ▸ | APP | P05067 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3534320 | 1.00 | BACE1 (0.75) | BACE1CTSDBACE2RENAPP | |
| SCHEMBL3537753 | 1.00 | BACE1 (0.75) | BACE1CTSDBACE2RENAPP | |
| SCHEMBL3533029 | 0.87 | BACE1 (0.66) | BACE1CTSDBACE2REN | |
| SCHEMBL3541368 | 0.87 | BACE1 (0.66) | BACE1CTSDBACE2REN | |
| SCHEMBL3534104 | 0.87 | BACE1 (0.66) | BACE1CTSDBACE2REN | |
| SCHEMBL20814013 | 0.86 | BACE1 (1.00) | BACE1CTSDBACE2REN | |
| SCHEMBL16291165 | 0.85 | BACE1 (0.84) | BACE1CTSDBACE2RENAPP | |
| SCHEMBL4737569 | 0.85 | BACE1 (0.61) | BACE1CTSDBACE2 | |
| SCHEMBL3530473 | 0.84 | BACE1 (0.79) | BACE1CTSDBACE2RENAPP | |
| SCHEMBL3535871 | 0.84 | BACE1 (0.79) | BACE1CTSDBACE2RENAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7700602-B2 | Amino-5,5-diphenylimidazolone derivatives for the inhibition of β-secretase | WYETH LLC (US) | 2010-04-20 | — | — | US | disclosed |
| US-7700602-B2 | Amino-5,5-diphenylimidazolone derivatives for the inhibition of β-secretase | WYETH LLC (US) | 2010-04-20 | — | — | US | disclosed |
| US-7700602-B2 | Amino-5,5-diphenylimidazolone derivatives for the inhibition of β-secretase | WYETH LLC (US) | 2010-04-20 | — | — | US | disclosed |
| EP-1756087-B1 | AMINO-5,5-DIPHENYLIMIDAZOLONE DERIVATIVES FOR THE INHIBITION OF BETA-SECRETASE | WYETH CORP (US) | 2009-10-07 | — | — | EP | disclosed |
| EP-1756087-B1 | AMINO-5,5-DIPHENYLIMIDAZOLONE DERIVATIVES FOR THE INHIBITION OF BETA-SECRETASE | WYETH CORP (US) | 2009-10-07 | — | — | EP | disclosed |
| US-20090093498-A1 | AMINO-5,5-DIPHENYLIMIDAZOLONE DERIVATIVES FOR THE INHIBITION OF BETA-SECRETASE | WYETH (US) | 2009-04-09 | — | — | US | disclosed |
| US-20090093498-A1 | AMINO-5,5-DIPHENYLIMIDAZOLONE DERIVATIVES FOR THE INHIBITION OF BETA-SECRETASE | WYETH (US) | 2009-04-09 | — | — | US | disclosed |
| US-20090093498-A1 | AMINO-5,5-DIPHENYLIMIDAZOLONE DERIVATIVES FOR THE INHIBITION OF BETA-SECRETASE | WYETH (US) | 2009-04-09 | — | — | US | disclosed |
| US-7482349-B2 | Amino-5,5-diphenylimidazolone derivatives for the inhibition of β-secretase | WYETH (US) | 2009-01-27 | — | — | US | disclosed |
| US-7482349-B2 | Amino-5,5-diphenylimidazolone derivatives for the inhibition of β-secretase | WYETH (US) | 2009-01-27 | — | — | US | disclosed |
| US-7482349-B2 | Amino-5,5-diphenylimidazolone derivatives for the inhibition of β-secretase | WYETH (US) | 2009-01-27 | — | — | US | disclosed |
| WO-2006009653-A1 | AMINO-5,5-DIPHENYLIMIDAZOLONE DERIVATIVES FOR THE INHIBITION OF BETA-SECRETASE | WYETH (US) | 2006-01-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090093498-A1 | AMINO-5,5-DIPHENYLIMIDAZOLONE DERIVATIVES FOR THE INHIBITION OF BETA-SECRETASE | BACE1, BACE2, APP | BACE1 1/4885CTSD 158/4885BACE2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.