Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | FASN | P49327 | 2/20 | 0.40 |
| ▸ | FNTA | P49354 | 1/20 | 0.39 |
| ▸ | FNTB | P49356 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3545359 | 0.93 | HRH3 (0.52) | HRH3CYP2D6FASNMGLL | |
| SCHEMBL3547541 | 0.92 | HRH3 (0.57) | HRH3HPGDF10CYP2D6MEN1 | |
| SCHEMBL3538084 | 0.90 | HRH3 (0.50) | HRH3HPGDCYP2D6MGLL | |
| SCHEMBL3539938 | 0.87 | HRH3 (0.58) | HRH3HPGDF10CYP2D6MEN1 | |
| SCHEMBL3538048 | 0.84 | HRH3 (0.53) | HRH3HPGDCYP2D6 | |
| SCHEMBL3538457 | 0.84 | HRH3 (0.53) | HRH3HPGDCYP2D6MEN1KMT2A | |
| SCHEMBL3536554 | 0.83 | HRH3 (0.47) | HRH3HPGDKMT2AMGLL | |
| SCHEMBL3539964 | 0.83 | HRH3 (0.55) | HRH3HPGDCYP2D6MEN1KMT2A | |
| SCHEMBL3541794 | 0.83 | HRH3 (0.55) | HRH3CYP2D6MGLL | |
| SCHEMBL3543802 | 0.82 | HPGD (0.52) | HRH3HPGDF10MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7723325-B2 | 5-amido-indole-2-carboxamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2010-05-25 | — | — | US | disclosed |
| US-20090264418-A1 | 5-AMIDO-INDOLE-2-CARBOXAMIDE DERIVATIVES | NETTEKOVEN MATTHIAS | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264418-A1 | 5-AMIDO-INDOLE-2-CARBOXAMIDE DERIVATIVES | HRH4, HRH3, CNR2 | HRH3 2/4885HPGD 810/4885F10 2489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.