Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 20/20 | 1.00 |
| ▸ | JAK2 | O60674 | 4/20 | 0.77 |
| ▸ | JAK1 | P23458 | 3/20 | 0.77 |
| ▸ | CDK9 | P50750 | 1/20 | 0.77 |
| ▸ | JAK3 | P52333 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12990018 | 0.93 | TYK2 (0.87) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL3549338 | 0.89 | TYK2 (1.00) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL12988169 | 0.88 | TYK2 (0.80) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL1707038 | 0.88 | TYK2 (0.84) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL3533227 | 0.87 | TYK2 (1.00) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL3515230 | 0.87 | TYK2 (1.00) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL3568268 | 0.86 | TYK2 (1.00) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL12989573 | 0.86 | TYK2 (1.00) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL3541180 | 0.85 | TYK2 (1.00) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL3575721 | 0.84 | TYK2 (1.00) | TYK2JAK2JAK1CDK9JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240182935-A1 | METHOD OF PRODUCING & PROCESSING DIAMINES | AGAIN BIO APS (DK) | 2024-06-06 | — | — | US | disclosed |
| US-11834690-B2 | Microorganisms and methods for the biosynthesis of adipate, hexamethylenediamine and 6-aminocaproic acid | GENOMATICA, INC. (US) | 2023-12-05 | — | — | US | disclosed |
| US-20230348865-A1 | ENGINEERED ENZYMES AND METHODS OF MAKING AND USING | AGAIN BIO APS (DK) | 2023-11-02 | — | — | US | disclosed |
| US-11702682-B2 | Method of producing and processing diamines to a diamine free base using a carbonate intermediate and an engineered microorganism | GENOMATICA, INC. (US) | 2023-07-18 | — | — | US | disclosed |
| US-20230022727-A1 | MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF ADIPATE, HEXAMETHYLENEDIAMINE AND 6-AMINOCAPROIC ACID | GENOMATICA INC (US) | 2023-01-26 | — | — | US | disclosed |
| US-11208673-B2 | Microorganisms and methods for the biosynthesis of adipate, hexamethylenediamine and 6-aminocaproic acid | GENOMATICA, INC. (US) | 2021-12-28 | — | — | US | disclosed |
| US-20210130861-A1 | METHOD OF PRODUCING & PROCESSING DIAMINES | AGAIN BIO APS (DK) | 2021-05-06 | — | — | US | disclosed |
| US-10711289-B2 | Method of producing and processing diamines from an engineered microorganism | GENOMATICA, INC. (US) | 2020-07-14 | — | — | US | disclosed |
| US-20190330670-A1 | MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF ADIPATE, HEXAMETHYLENEDIAMINE AND 6-AMINOCAPROIC ACID | AGAIN BIO APS (DK) | 2019-10-31 | — | — | US | disclosed |
| US-10150977-B2 | Microorganisms and methods for the biosynthesis of adipate, hexamethylenediamine and 6-aminocaproic acid | GENOMATICA, INC. (US) | 2018-12-11 | — | — | US | disclosed |
| US-20130303723-A1 | MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF ADIPATE, HEXAMETHYLENEDIAMINE AND 6-AMINOCAPROIC ACID | AGAIN BIO APS (DK) | 2013-11-14 | — | — | US | disclosed |
| US-8486950-B2 | Janus kinase inhibitor compounds and methods | F. HOFFMANN-LA ROCHE AG (CH) | 2013-07-16 | — | — | US | disclosed |
| US-8486950-B2 | Janus kinase inhibitor compounds and methods | F. HOFFMANN-LA ROCHE AG (CH) | 2013-07-16 | — | — | US | disclosed |
| US-8377680-B2 | Microorganisms and methods for the biosynthesis of adipate, hexamethylenediamine and 6-aminocaproic acid | GENOMATICA, INC. (US) | 2013-02-19 | — | — | US | disclosed |
| US-20120282661-A1 | MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF ADIPATE, HEXAMETHYLENEDIAMINE AND 6-AMINOCAPROIC ACID | GENOMATICA, INC. (US) | 2012-11-08 | — | — | US | disclosed |
| US-20100317069-A1 | MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF ADIPATE, HEXAMETHYLENEDIAMINE AND 6-AMINOCAPROIC ACID | AGAIN BIO APS (DK) | 2010-12-16 | — | — | US | disclosed |
| WO-2010142752-A1 | JANUS KINASE INHIBITOR COMPOUNDS AND METHODS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-12-16 | — | — | WO | disclosed |
| US-20100317643-A1 | JANUS KINASE INHIBITOR COMPOUNDS AND METHODS | GENENTECH, INC. (US) | 2010-12-16 | — | — | US | disclosed |
| US-20100317643-A1 | JANUS KINASE INHIBITOR COMPOUNDS AND METHODS | GENENTECH, INC. (US) | 2010-12-16 | — | — | US | disclosed |
| US-20100317643-A1 | JANUS KINASE INHIBITOR COMPOUNDS AND METHODS | GENENTECH, INC. (US) | 2010-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317643-A1 | JANUS KINASE INHIBITOR COMPOUNDS AND METHODS | JAK2, JAK1, JAK3 | TYK2 21/4885JAK2 1/4885JAK1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.