Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 17/20 | 0.55 |
| ▸ | CHUK | O15111 | 14/20 | 0.55 |
| ▸ | CDK2 | P24941 | 1/20 | 0.55 |
| ▸ | BTK | Q06187 | 1/20 | 0.55 |
| ▸ | ITK | Q08881 | 1/20 | 0.55 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.55 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | NPR1 | P16066 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3548046 | 0.95 | IKBKB (0.50) | IKBKBCHUKCDK2BTKITK | |
| SCHEMBL3544016 | 0.91 | IKBKB (0.46) | IKBKBCHUKCDK2BTKITK | |
| SCHEMBL3548558 | 0.91 | IKBKB (0.46) | IKBKBCHUKCDK2BTKITK | |
| SCHEMBL3543608 | 0.90 | IKBKB (0.45) | IKBKBCHUKCDK2BTKITK | |
| SCHEMBL3552707 | 0.90 | IKBKB (0.44) | IKBKBCHUKCDK2BTKITK | |
| SCHEMBL3546968 | 0.90 | IKBKB (0.44) | IKBKBCHUKCDK2BTKITK | |
| SCHEMBL3544075 | 0.89 | IKBKB (0.45) | IKBKBCHUKCDK2BTKITK | |
| SCHEMBL3546280 | 0.89 | CHKA (0.46) | IKBKBCHUKCDK2BTKITK | |
| SCHEMBL3545712 | 0.88 | IKBKB (0.68) | IKBKBCHUKCDK2BTKITK | |
| SCHEMBL3551480 | 0.88 | IKBKB (0.43) | IKBKBCHUKCDK2BTKITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7683171-B2 | N,1-Dimethyl-7-phenyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-4-amine; treating inflammatory and immune diseases; cancer; I kappa B kinase (IKK) inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-03-23 | — | — | US | claimed |