Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25A | P30304 | 1/20 | 0.52 |
| ▸ | CDC25B | P30305 | 1/20 | 0.52 |
| ▸ | CDC25C | P30307 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3548778 | 0.86 | CDC25A (0.60) | CDC25ACDC25BCDC25CALDH1A1TSHR | |
| SCHEMBL3546750 | 0.84 | CDC25A (0.55) | CDC25ACDC25BCDC25CALDH1A1TSHR | |
| SCHEMBL3556819 | 0.83 | CDC25A (0.51) | CDC25ACDC25BCDC25CALDH1A1TSHR | |
| SCHEMBL3549004 | 0.83 | CDC25A (0.57) | CDC25ACDC25BCDC25CALDH1A1TSHR | |
| SCHEMBL3552480 | 0.82 | CDC25A (0.53) | CDC25ACDC25BCDC25CALDH1A1TSHR | |
| SCHEMBL3553179 | 0.82 | CDC25A (0.51) | CDC25ACDC25BCDC25CALDH1A1TSHR | |
| SCHEMBL5311993 | 0.79 | CDC25A (0.61) | CDC25ACDC25BCDC25CKMT2ANPSR1 | |
| SCHEMBL3550519 | 0.79 | CDC25A (0.49) | CDC25ACDC25BCDC25CALDH1A1TSHR | |
| SCHEMBL3555886 | 0.78 | CDC25A (0.49) | CDC25ACDC25BCDC25CALDH1A1TSHR | |
| SCHEMBL2400569 | 0.75 | POLB (0.41) | CDC25ACDC25BCDC25CALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100317658-A1 | 4,7-Dioxobenzothiazole-2-Carboxamide Derivatives, Their Preparation And Their Therapeutic Uses | IPSEN PHARMA S.A.S. (FR) | 2010-12-16 | — | — | US | claimed |
| US-7795284-B2 | 4,7-dioxobenzothiazole-2-carboxamide derivatives, their preparation and their therapeutic uses | IPSEN PHARMA S.A.S. (FR) | 2010-09-14 | — | — | US | claimed |
| EP-1814879-B1 | DERIVATIVES OF 4,7-DIOXOBENZOTHIAZOLE-2-CARBOXAMIDES, PREPARATION METHOD THEREOF AND THERAPEUTIC USES OF SAME | SOD CONSEILS RECH APPLIC (FR) | 2008-09-24 | — | — | EP | claimed |
| US-20070244186-A1 | 4, 7-Dioxobenzothiazole-2-Carboxamide Derivatives, Their Preparation and Their Therapeutic Uses | IPSEN PHARMA S.A.S. (FR) | 2007-10-18 | — | — | US | claimed |
| EP-1814879-A1 | DERIVATIVES OF 4,7-DIOXOBENZOTHIAZOLE-2-CARBOXAMIDES, PREPARATION METHOD THEREOF AND THERAPEUTIC USES OF SAME | Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S) SAS (FR) | 2007-08-08 | — | — | EP | claimed |
| WO-2006051202-A1 | DERIVATIVES OF 4,7-DIOXOBENZOTHIAZOLE-2-CARBOXAMIDES, PREPARATION METHOD THEREOF AND THERAPEUTIC USES OF SAME | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) SAS (FR) | 2006-05-18 | — | — | WO | claimed |
| US-20100317658-A1 | 4,7-Dioxobenzothiazole-2-Carboxamide Derivatives, Their Preparation And Their Therapeutic Uses | IPSEN PHARMA S.A.S. (FR) | 2010-12-16 | — | — | US | disclosed |
| US-7795284-B2 | 4,7-dioxobenzothiazole-2-carboxamide derivatives, their preparation and their therapeutic uses | IPSEN PHARMA S.A.S. (FR) | 2010-09-14 | — | — | US | disclosed |
| EP-1814879-B1 | DERIVATIVES OF 4,7-DIOXOBENZOTHIAZOLE-2-CARBOXAMIDES, PREPARATION METHOD THEREOF AND THERAPEUTIC USES OF SAME | SOD CONSEILS RECH APPLIC (FR) | 2008-09-24 | — | — | EP | disclosed |
| US-20070244186-A1 | 4, 7-Dioxobenzothiazole-2-Carboxamide Derivatives, Their Preparation and Their Therapeutic Uses | IPSEN PHARMA S.A.S. (FR) | 2007-10-18 | — | — | US | disclosed |
| EP-1814879-A1 | DERIVATIVES OF 4,7-DIOXOBENZOTHIAZOLE-2-CARBOXAMIDES, PREPARATION METHOD THEREOF AND THERAPEUTIC USES OF SAME | Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S) SAS (FR) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006051202-A1 | DERIVATIVES OF 4,7-DIOXOBENZOTHIAZOLE-2-CARBOXAMIDES, PREPARATION METHOD THEREOF AND THERAPEUTIC USES OF SAME | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) SAS (FR) | 2006-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070244186-A1 | 4, 7-Dioxobenzothiazole-2-Carboxamide Derivatives, Their Preparation and Their Therapeutic Uses | CDC25C, CDC25A, CDC25B | CDC25A 2/4885CDC25B 3/4885CDC25C 1/4885 |
| US-20100317658-A1 | 4,7-Dioxobenzothiazole-2-Carboxamide Derivatives, Their Preparation And Their Therapeutic Uses | CDC25C, CDC25A, CDC25B | CDC25A 2/4885CDC25B 3/4885CDC25C 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.