Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 14/20 | 0.70 |
| ▸ | PDE4A | P27815 | 9/20 | 0.70 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.70 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3544551 | 0.92 | PDE4A (0.61) | PDE4BPDE4APDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL3541142 | 0.92 | PDE4A (0.61) | PDE4BPDE4APDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL27600696 | 0.92 | PDE4B (0.63) | PDE4BPDE4APDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL3548425 | 0.90 | PDE4A (0.60) | PDE4BPDE4APDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL3546194 | 0.89 | PDE4A (0.57) | PDE4BPDE4APDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL3543472 | 0.88 | PDE4A (0.56) | PDE4BPDE4APDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL5366967 | 0.87 | PDE4B (0.66) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL3540908 | 0.86 | PDE4A (0.60) | PDE4BPDE4APDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL27600683 | 0.86 | PDE4A (0.62) | PDE4BPDE4APDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL3544816 | 0.86 | PDE4A (0.62) | PDE4BPDE4APDE4CPDE4DSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7696198-B2 | Phosphodiesterase 4 inhibitors | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-04-13 | — | — | US | disclosed |
| US-7696198-B2 | Phosphodiesterase 4 inhibitors | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-04-13 | — | — | US | disclosed |
| US-7696198-B2 | Phosphodiesterase 4 inhibitors | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-04-13 | — | — | US | disclosed |
| US-20090306156-A1 | PHOSPHODIESTERASE 4 INHIBITORS | HOPPER ALLEN | 2009-12-10 | — | — | US | disclosed |
| US-7585882-B2 | Phosphodiesterase 4 inhibitors | MEMORY PHARMACEUTICALS CORPORATION (US) | 2009-09-08 | — | — | US | disclosed |
| US-7585882-B2 | Phosphodiesterase 4 inhibitors | MEMORY PHARMACEUTICALS CORPORATION (US) | 2009-09-08 | — | — | US | disclosed |
| US-20090176799-A1 | PHOSPHODIESTERASE 4 INHIBITORS | RUIPING LIU | 2009-07-09 | — | — | US | disclosed |
| US-7235579-B2 | Phosphodiesterase 4 inhibitors | MEMORY PHARMACEUTICALS CORP. (US) | 2007-06-26 | — | — | US | disclosed |
| WO-2006044955-A1 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2006-04-27 | — | — | WO | disclosed |
| EP-1613590-A2 | 4-(3,4-DISUBSTITUTED PHENYL)-PYRROLIDIN-2-ONE COMPOUNDS AS PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceutical Corporation (US) | 2006-01-11 | — | — | EP | disclosed |
| US-20050272803-A1 | Phosphodiesterase 4 inhibitors | RUIPING LIU | 2005-12-08 | — | — | US | disclosed |
| CN-1604776-A | 4-4-alkoxy-3-hydroxyphenyl-2-pyrrolidone derivatives as pde-4 inhibitors for the treatment of neurological syndromes | MEMORY PHARM CORP (US) | 2005-04-06 | — | — | CN | disclosed |
| US-20050026913-A1 | Phosphodiesterase 4 inhibitors | MEMORY PHARMACEUTICALS CORPORATION | 2005-02-03 | — | — | US | disclosed |
| WO-2004094375-A2 | 4 - (3,4 - DISUBSTITUTED PHENYL) - PYRROLIDIN-2-ONE COMPOUNDS AS PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2004-11-04 | — | — | WO | disclosed |
| WO-2004094375-A2 | 4 - (3,4 - DISUBSTITUTED PHENYL) - PYRROLIDIN-2-ONE COMPOUNDS AS PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2004-11-04 | — | — | WO | disclosed |
| US-20030139406-A1 | Phosphodiesterase 4 inhibitors | MEMORY PHARMACEUTICALS CORP. | 2003-07-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030139406-A1 | Phosphodiesterase 4 inhibitors | PDE12, PDE4A, PDE5A | PDE4B 7/4885PDE4A 2/4885PDE4C 8/4885 |
| US-20090176799-A1 | PHOSPHODIESTERASE 4 INHIBITORS | PDE4A, PDE12, PDE3B | PDE4B 5/4885PDE4A 1/4885PDE4C 8/4885 |
| US-20050026913-A1 | Phosphodiesterase 4 inhibitors | PDE4A, PDE12, PDE3B | PDE4B 5/4885PDE4A 1/4885PDE4C 8/4885 |
| US-20050272803-A1 | Phosphodiesterase 4 inhibitors | PDE4A, PDE12, PDE3B | PDE4B 5/4885PDE4A 1/4885PDE4C 8/4885 |
| US-20090306156-A1 | PHOSPHODIESTERASE 4 INHIBITORS | PDE4A, PDE3B, PDE5A | PDE4B 5/4885PDE4A 1/4885PDE4C 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.