Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 17/20 | 0.52 |
| ▸ | CHUK | O15111 | 7/20 | 0.50 |
| ▸ | NPR1 | P16066 | 1/20 | 0.45 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3541768 | 0.91 | IKBKB (0.49) | IKBKBCHUKNPR1PDE7A | |
| SCHEMBL3542136 | 0.87 | IKBKB (0.67) | IKBKBCHUK | |
| SCHEMBL3549854 | 0.80 | IKBKB (0.46) | IKBKBCHUKPDE7ARAD52 | |
| SCHEMBL3545657 | 0.80 | TLR7 (0.49) | IKBKBCHUKPDE7ARAD52 | |
| SCHEMBL3548041 | 0.78 | IKBKB (0.61) | IKBKBCHUK | |
| SCHEMBL3548555 | 0.78 | IKBKB (0.60) | IKBKBCHUK | |
| SCHEMBL22145812 | 0.77 | IKBKB (0.56) | IKBKBCHUK | |
| SCHEMBL3550625 | 0.75 | CDK2 (0.46) | IKBKBCHUK | |
| SCHEMBL3545712 | 0.74 | IKBKB (0.68) | IKBKBCHUK | |
| SCHEMBL3553461 | 0.73 | IKBKB (0.53) | IKBKBCHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7683171-B2 | N,1-Dimethyl-7-phenyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-4-amine; treating inflammatory and immune diseases; cancer; I kappa B kinase (IKK) inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-03-23 | — | — | US | claimed |
| US-7683171-B2 | N,1-Dimethyl-7-phenyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-4-amine; treating inflammatory and immune diseases; cancer; I kappa B kinase (IKK) inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-03-23 | — | — | US | disclosed |
| US-7683171-B2 | N,1-Dimethyl-7-phenyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-4-amine; treating inflammatory and immune diseases; cancer; I kappa B kinase (IKK) inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-03-23 | — | — | US | disclosed |
| WO-2007044050-A2 | 1H-IMIDAZO[4,5-D]THIENO[3,2-B]PYRIDINE BASED TRICYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-04-19 | — | — | WO | disclosed |