⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8300087 | 0.57 | — | — | |
| SCHEMBL4957362 | 0.57 | — | — | |
| SCHEMBL2731837 | 0.48 | — | — | |
| SCHEMBL3675158 | 0.48 | — | — | |
| SCHEMBL1295853 | 0.48 | — | — | |
| SCHEMBL456468 | 0.48 | — | — | |
| SCHEMBL14981214 | 0.48 | — | — | |
| SCHEMBL1295855 | 0.48 | — | — | |
| SCHEMBL2695895 | 0.48 | — | — | |
| SCHEMBL14348032 | 0.48 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 359 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2665716-B1 | METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF FUSED AMINODIHYDROTHIAZINE DERIVATIVES | EISAI R&D MAN CO LTD (JP) | 2017-03-08 | — | — | EP | claimed |
| US-4742054-A | Treatment of mammals suffering from damage to the central nervous system | NAFTCHI NOSRAT E (US) | 1988-05-03 | — | — | US | claimed |
| WO-2024011150-A2 | CNS TARGETING COMPLEXES AND USES THEREOF | DYNE THERAPEUTICS, INC. (US) | 2024-01-11 | — | — | WO | disclosed |
| CN-107106568-B | Pharmaceutical compositions of fused aminodihydrothiazine derivatives | 卫材R&D管理有限公司 | 2023-09-26 | — | — | CN | disclosed |
| CN-107106568-B | Pharmaceutical compositions of fused aminodihydrothiazine derivatives | 卫材R&D管理有限公司 | 2023-09-26 | — | — | CN | disclosed |
| WO-2023023189-A2 | CLUSTERIN OVEREXPRESSION IN ALZHEIMER'S DISEASE | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2023-02-23 | — | — | WO | disclosed |
| EP-3555106-B1 | BICYCLIC THIAZINE AND OXAZINE DERIVATIVES AS BETA-SECRETASE INHIBITORS AND METHODS OF USE | AMGEN INC (US) | 2022-03-09 | — | — | EP | disclosed |
| EP-3205343-B1 | PHARMACEUTICAL COMPOSITION OF FUSED AMINODIHYDROTHIAZINE DERIVATIVE | EISAI R&D MAN CO LTD (JP) | 2022-01-26 | — | — | EP | disclosed |
| US-20210355138-A1 | AMINOTHIAZINIES AND THEIR USE AS BACE1 INHIBITORS | LILLY CO ELI (US) | 2021-11-18 | — | — | US | disclosed |
| EP-3414253-B1 | C5-C6-OXACYLIC FUSED IMINOTHIAZINE DIOXIDE COMPOUNDS BEARING AN ETHER LINKER AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME (US) | 2021-07-21 | — | — | EP | disclosed |
| US-11008338-B2 | C5-C6-oxacyclic fused iminothiazine dioxide compounds bearing an ether linker as BACE inhibitors, compositions, and their use | MERCK SHARP & DOHME CORP. (US) | 2021-05-18 | — | — | US | disclosed |
| EP-2151435-A1 | PHARMACEUTICAL COMPOSITION FOR TREATMENT OF ALZHEIMER'S DISEASE | Shionogi&Co., Ltd. (JP) | 2010-02-10 | — | — | EP | disclosed |
| WO-2010013794-A1 | SPIROAMINODIHYDROTHIAZINE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-02-04 | — | — | WO | disclosed |
| EP-2147914-A1 | AMINODIHYDROTHIAZINE DERIVATIVES SUBSTITUTED WITH CYCLIC GROUPS | Shionogi&Co., Ltd. (JP) | 2010-01-27 | — | — | EP | disclosed |
| US-20090209755-A1 | FUSED AMINODIHYDROTHIAZINE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-08-20 | — | — | US | disclosed |
| US-20090082560-A1 | AMINODIHYDROTHIAZINE DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 2009-03-26 | — | — | US | disclosed |
| CN-101346357-A | Aminodihydrothiazine derivatives | SHIONOGI & CO (JP) | 2009-01-14 | — | — | CN | disclosed |
| EP-1942105-A1 | AMINODIHYDROTHIAZINE DERIVATIVE | Shionogi Co., Ltd. (JP) | 2008-07-09 | — | — | EP | disclosed |
| US-4855325-A | Treatment of mammals suffering from damage to the central nervous system | NAFTCHI NOSRAT E (US) | 1989-08-08 | — | — | US | disclosed |
| US-4742054-A | Treatment of mammals suffering from damage to the central nervous system | NAFTCHI NOSRAT E (US) | 1988-05-03 | — | — | US | disclosed |