Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 20/20 | 1.00 |
| ▸ | PDE4B | Q07343 | 14/20 | 1.00 |
| ▸ | PDE4C | Q08493 | 14/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 14/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.60 |
| ▸ | VEGFA | P15692 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | PDE5A | O76074 | 1/20 | 0.60 |
| ▸ | TNF | P01375 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | BLM | P54132 | 1/20 | 0.60 |
| ▸ | PDE1A | P54750 | 1/20 | 0.60 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9341618 | 1.00 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL13439292 | 1.00 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL3551708 | 0.89 | PDE4A (0.80) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL3542652 | 0.88 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL3549567 | 0.87 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL4458628 | 0.85 | PDE4A (0.74) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL4466602 | 0.85 | PDE4A (0.74) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL3539960 | 0.85 | PDE4A (0.74) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL4197597 | 0.85 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL4199760 | 0.85 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4DCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0437555-A1 | PROCESS FOR THE RACEMIC SEPARATION OF 4-ARYL-2-OXO-PYRROLIDINE-3-CARBOXYLIC ACID ESTERS. | SCHERING AG (DE) | 1991-07-24 | — | — | EP | claimed |
| WO-1991000362-A1 | PROCESS FOR THE RACEMIC SEPARATION OF 4-ARYL-2-OXO-PYRROLIDINE-3-CARBOXYLIC ACID ESTERS | SCHERING AKTIENGESELLSCHAFT (DE) | 1991-01-10 | — | — | WO | claimed |
| US-4193926-A | 4-(Polyalkoxy phenyl)-2-pyrrolidones | SCHERING AKTIENGESELLSCHAFT (DE) | 1980-03-18 | — | — | US | claimed |
| US-4012495-A | USED IN TREATING NEUROLOGICAL AND PSYCHIC DISORDERS | SCHERING AKTIENGESELLSCHAFT (DT) | 1977-03-15 | — | — | US | claimed |
| US-7696198-B2 | Phosphodiesterase 4 inhibitors | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-04-13 | — | — | US | disclosed |
| US-20090306156-A1 | PHOSPHODIESTERASE 4 INHIBITORS | HOPPER ALLEN | 2009-12-10 | — | — | US | disclosed |
| US-7601742-B2 | 4-(3-Hydroxy-4-methoxyphenyl)-pyrrolidin-2-one and derivatives; reverse transcriptase inhibitors; AIDS | IRM LLC (BM) | 2009-10-13 | — | — | US | disclosed |
| US-7601742-B2 | 4-(3-Hydroxy-4-methoxyphenyl)-pyrrolidin-2-one and derivatives; reverse transcriptase inhibitors; AIDS | IRM LLC (BM) | 2009-10-13 | — | — | US | disclosed |
| US-7601742-B2 | 4-(3-Hydroxy-4-methoxyphenyl)-pyrrolidin-2-one and derivatives; reverse transcriptase inhibitors; AIDS | IRM LLC (BM) | 2009-10-13 | — | — | US | disclosed |
| EP-1435944-B1 | 4(4-ALKOXY-3-HYDROXYPHENYL)-2-PYRROLIDONE DERIVATIVES AS PDE-4 INHIBITORS FOR THE TREATMENT OF NEUROLOGICAL SYNDROMES | MEMORY PHARM CORP (US) | 2009-09-30 | — | — | EP | disclosed |
| US-7585882-B2 | Phosphodiesterase 4 inhibitors | MEMORY PHARMACEUTICALS CORPORATION (US) | 2009-09-08 | — | — | US | disclosed |
| US-20090176799-A1 | PHOSPHODIESTERASE 4 INHIBITORS | RUIPING LIU | 2009-07-09 | — | — | US | disclosed |
| US-20030139406-A1 | Phosphodiesterase 4 inhibitors | MEMORY PHARMACEUTICALS CORP. | 2003-07-24 | — | — | US | disclosed |
| WO-2003032981-A1 | 4-(4-ALKOXY-3-HYDROXYPHENYL)-2-PYRROLIDONE DERIVATIVES AS PDE-4 INHIBITORS FOR THE TREATMENT OF NEUROLOGICAL SYNDROMES | MEMORY PHARMACEUTICALS CORPORATION (US) | 2003-04-24 | — | — | WO | disclosed |
| US-5539111-A | Process for resolution of racemates of 4-aryl-2-oxo-pyrrolidine-3-carboxylic acid esters | SCHERING AKTIENGESELLSCHAFT (DE) | 1996-07-23 | — | — | US | disclosed |
| EP-0437555-B1 | PROCESS FOR THE RACEMIC SEPARATION OF 4-ARYL-2-OXO-PYRROLIDINE-3-CARBOXYLIC ACID ESTERS | SCHERING AG (DE) | 1995-08-30 | — | — | EP | disclosed |
| EP-0437555-A1 | PROCESS FOR THE RACEMIC SEPARATION OF 4-ARYL-2-OXO-PYRROLIDINE-3-CARBOXYLIC ACID ESTERS. | SCHERING AG (DE) | 1991-07-24 | — | — | EP | disclosed |
| WO-1991000362-A1 | PROCESS FOR THE RACEMIC SEPARATION OF 4-ARYL-2-OXO-PYRROLIDINE-3-CARBOXYLIC ACID ESTERS | SCHERING AKTIENGESELLSCHAFT (DE) | 1991-01-10 | — | — | WO | disclosed |
| US-4193926-A | 4-(Polyalkoxy phenyl)-2-pyrrolidones | SCHERING AKTIENGESELLSCHAFT (DE) | 1980-03-18 | — | — | US | disclosed |
| US-4012495-A | USED IN TREATING NEUROLOGICAL AND PSYCHIC DISORDERS | SCHERING AKTIENGESELLSCHAFT (DT) | 1977-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030139406-A1 | Phosphodiesterase 4 inhibitors | PDE12, PDE4A, PDE5A | PDE4A 2/4885PDE4B 7/4885PDE4C 8/4885 |
| US-20090176799-A1 | PHOSPHODIESTERASE 4 INHIBITORS | PDE4A, PDE12, PDE3B | PDE4A 1/4885PDE4B 5/4885PDE4C 8/4885 |
| US-20090306156-A1 | PHOSPHODIESTERASE 4 INHIBITORS | PDE4A, PDE3B, PDE5A | PDE4A 1/4885PDE4B 5/4885PDE4C 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.