Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3552867 | 0.87 | MAPK14 (1.00) | MAPK14RPS6KB1MAPK13MAPK12MAPK11 | |
| SCHEMBL3549533 | 0.85 | MAPK14 (1.00) | MAPK14KDM4EALDH1A1MAPTRAB9A | |
| SCHEMBL3547903 | 0.82 | MAPK14 (1.00) | MAPK14RPS6KB1MAPK13MAPK12MAPK11 | |
| SCHEMBL3549470 | 0.80 | MAPK14 (1.00) | MAPK14RPS6KB1MAPK13MAPK12MAPK11 | |
| SCHEMBL3552734 | 0.76 | MAPK14 (1.00) | MAPK14RPS6KB1RAF1MAPK13MAPK12 | |
| SCHEMBL3194760 | 0.74 | MAPK14 (0.70) | MAPK14MAPTMAPK13MAPK12MAPK11 | |
| SCHEMBL3549267 | 0.73 | MAPK14 (0.83) | MAPK14RPS6KB1MAPK13MAPK12MAPK11 | |
| SCHEMBL3545324 | 0.73 | MAPK14 (0.82) | MAPK14RPS6KB1MAPK13MAPK12MAPK11 | |
| SCHEMBL3543192 | 0.72 | MAPK14 (0.65) | MAPK14KDM4EMAPTRAB9ARPS6KB1 | |
| SCHEMBL3549747 | 0.72 | MAPK14 (0.81) | MAPK14RPS6KB1MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060167247-A1 | Urea inhibitors of MAP kinases | LOCUS PHARMACEUTICALS, INC. | 2006-07-27 | — | — | US | claimed |
| US-7741479-B2 | Urea inhibitors of MAP kinases | LOCUS PHARMACEUTICALS, INC. (US) | 2010-06-22 | — | — | US | disclosed |
| EP-1828169-A2 | UREA INHIBITORS OF MAP KINASES | Locus Pharmaceuticals, Inc. (US) | 2007-09-05 | — | — | EP | disclosed |
| US-20060167247-A1 | Urea inhibitors of MAP kinases | LOCUS PHARMACEUTICALS, INC. | 2006-07-27 | — | — | US | disclosed |
| WO-2006062982-A2 | UREA INHIBITORS OF MAP KINASES | LOCUS PHARMACEUTICALS, INC. (US) | 2006-06-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060167247-A1 | Urea inhibitors of MAP kinases | MAPK1, MAP3K1, MAP3K20 | MAPK14 47/4885KDM4E 1734/4885ALDH1A1 2027/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.