Sugi Predict

Sugi Predict / Compounds / SCHEMBL3548366

SCHEMBL3548366

SCHEMBL3548366

CCCc1cc(C(=O)c2ccc(OC)c(F)c2)ccc1Oc1cccc([C@@]2(C)OC(=O)NC2=O)c1

nearest known ligand 0.38

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ PPARG P37231 6/20 0.38
▸ PPARD Q03181 2/20 0.38
▸ PPARA Q07869 2/20 0.38
▸ ACHE P22303 1/20 0.37
▸ NR1H2 P55055 5/20 0.35
▸ NR1H3 Q13133 4/20 0.35
▸ TAS1R3 Q7RTX0 1/20 0.35
▸ TAS1R1 Q7RTX1 1/20 0.35
▸ PTGER3 P43115 1/20 0.35
▸ MAPK1 P28482 2/20 0.34
▸ LMNA P02545 1/20 0.34
▸ HTT P42858 1/20 0.34
▸ RAB9A P51151 1/20 0.34
▸ HCAR2 Q8TDS4 1/20 0.34
▸ ALDH1A1 P00352 1/20 0.34
▸ HPGD P15428 1/20 0.34
▸ FOS P01100 1/20 0.33
▸ JUN P05412 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3547512 0.91 PPARG (0.41) PPARGPPARDPPARANR1H2NR1H3
SCHEMBL3552987 0.91 PPARG (0.41) PPARGPPARDPPARANR1H2NR1H3
SCHEMBL3551254 0.91 PPARG (0.41) PPARGPPARDPPARANR1H2NR1H3
SCHEMBL3553710 0.89 HCAR2 (0.38) PPARGPPARDPPARANR1H2NR1H3
SCHEMBL3549278 0.88 PPARG (0.41) PPARGPPARDPPARANR1H2NR1H3
SCHEMBL13134449 0.88 PPARG (0.41) PPARGPPARDPPARANR1H2NR1H3
SCHEMBL3546157 0.88 PPARG (0.39) PPARGPPARDPPARANR1H2NR1H3
SCHEMBL3547453 0.87 PPARG (0.49) PPARGPPARDPPARANR1H2NR1H3
SCHEMBL3549277 0.87 NPC1 (0.41) PPARGPPARDPPARANR1H2NR1H3
SCHEMBL3555006 0.86 PPARG (0.42) PPARGPPARDPPARANR1H2NR1H3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7807692-B2 Antidiabetic oxazolidinediones and thiazolidinediones MERCK SHARP & DOHME CORP. (US) 2010-10-05 — — US disclosed
US-7807692-B2 Antidiabetic oxazolidinediones and thiazolidinediones MERCK SHARP & DOHME CORP. (US) 2010-10-05 — — US disclosed
US-7807692-B2 Antidiabetic oxazolidinediones and thiazolidinediones MERCK SHARP & DOHME CORP. (US) 2010-10-05 — — US disclosed
US-20100168164-A1 Antidiabetic Oxazolidinediones and Thiazolidinediones MERCK SHARP & DOHME CORP. 2010-07-01 — — US disclosed
US-20100168164-A1 Antidiabetic Oxazolidinediones and Thiazolidinediones MERCK SHARP & DOHME CORP. 2010-07-01 — — US disclosed
US-20100168164-A1 Antidiabetic Oxazolidinediones and Thiazolidinediones MERCK SHARP & DOHME CORP. 2010-07-01 — — US disclosed
WO-2007008501-A1 ANTIDIABETIC OXAZOLIDINEDIONES AND THIAZOLIDINEDIONES MERCK & CO., INC. (US) 2007-01-18 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100168164-A1 Antidiabetic Oxazolidinediones and Thiazolidinediones PPARD, PPARA, PPARG PPARG 3/4885PPARD 1/4885PPARA 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.