Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3548628 | 1.00 | DPP4 (1.00) | DPP4DPP7 | |
| SCHEMBL3546227 | 0.81 | DPP4 (1.00) | DPP4DPP7 | |
| SCHEMBL3546231 | 0.81 | DPP4 (1.00) | DPP4DPP7 | |
| SCHEMBL3551398 | 0.79 | DPP4 (1.00) | DPP4DPP7 | |
| SCHEMBL3551399 | 0.79 | DPP4 (1.00) | DPP4DPP7 | |
| Fumaric Acid SCHEMBL6701204 | 0.77 | DPP4 (0.67) | DPP4DPP7 | |
| SCHEMBL7204376 | 0.75 | DPP4 (1.00) | DPP4DPP7 | |
| SCHEMBL7204365 | 0.75 | DPP4 (1.00) | DPP4DPP7 | |
| SCHEMBL7340857 | 0.75 | DPP4 (0.77) | DPP4DPP7 | |
| SCHEMBL7335885 | 0.75 | DPP4 (0.62) | DPP4DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7687504-B2 | 1-[3-[2-[2-cyano-(S)-pyrrolidin-1-yl]-2-oxo-ethylamino]-1-oxo-propyl]-4-[bis-(4-fluorophenyl)methyl]piperazine; inhibiting dipeptidyl peptidase IV or for treating Type II diabetes | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2010-03-30 | — | — | US | claimed |
| US-20050222222-A1 | Pyrrolidine compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2005-10-06 | — | — | US | claimed |
| US-7687504-B2 | 1-[3-[2-[2-cyano-(S)-pyrrolidin-1-yl]-2-oxo-ethylamino]-1-oxo-propyl]-4-[bis-(4-fluorophenyl)methyl]piperazine; inhibiting dipeptidyl peptidase IV or for treating Type II diabetes | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2010-03-30 | — | — | US | disclosed |
| US-7687504-B2 | 1-[3-[2-[2-cyano-(S)-pyrrolidin-1-yl]-2-oxo-ethylamino]-1-oxo-propyl]-4-[bis-(4-fluorophenyl)methyl]piperazine; inhibiting dipeptidyl peptidase IV or for treating Type II diabetes | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2010-03-30 | — | — | US | disclosed |
| US-20050222222-A1 | Pyrrolidine compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2005-10-06 | — | — | US | disclosed |
| WO-2005087235-A1 | PYRROLIDINE COMPOUNDS | NATIONAL HEALTH RESEARCH INSTITUTES (CN) | 2005-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222222-A1 | Pyrrolidine compounds | DPP4, DPP9, DPP7 | DPP4 1/4885DPP7 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.