Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 19/20 | 0.71 |
| ▸ | CHUK | O15111 | 11/20 | 0.71 |
| ▸ | RET | P07949 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.58 |
| ▸ | FLT4 | P35916 | 1/20 | 0.58 |
| ▸ | KDR | P35968 | 1/20 | 0.58 |
| ▸ | EPHB1 | P54762 | 1/20 | 0.58 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2766787 | 0.93 | IKBKB (0.82) | IKBKBCHUKRETCYP2C9EPHA1 | |
| SCHEMBL2767229 | 0.93 | IKBKB (0.71) | IKBKBCHUKRETCYP2C9EPHA1 | |
| SCHEMBL2767943 | 0.92 | IKBKB (0.70) | IKBKBCHUKRETCYP2C9EPHA1 | |
| SCHEMBL3554298 | 0.91 | IKBKB (0.81) | IKBKBCHUK | |
| SCHEMBL2767769 | 0.90 | IKBKB (0.73) | IKBKBCHUKRETCYP2C9EPHA1 | |
| SCHEMBL3036731 | 0.89 | IKBKB (0.67) | IKBKBCHUKRETCYP2C9EPHA1 | |
| SCHEMBL2767627 | 0.89 | IKBKB (0.72) | IKBKBCHUKRETCYP2C9EPHA1 | |
| SCHEMBL2766370 | 0.89 | IKBKB (0.71) | IKBKBCHUK | |
| SCHEMBL2768383 | 0.89 | IKBKB (0.83) | IKBKBCHUKRETCYP2C9EPHA1 | |
| SCHEMBL3042723 | 0.88 | IKBKB (0.72) | IKBKBCHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7737279-B2 | 1,6-dihydro-1,3,5,6-tetraaza-as-indacene based tricyclic compounds and pharmaceutical compositions comprising same | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-06-15 | — | — | US | claimed |