Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 12/20 | 0.59 |
| ▸ | RAF1 | P04049 | 5/20 | 0.59 |
| ▸ | KDR | P35968 | 4/20 | 0.49 |
| ▸ | WNT3A | P56704 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3543407 | 0.87 | BRAF (0.57) | BRAFRAF1KDRMAPK14CSF1R | |
| SCHEMBL13603508 | 0.86 | BRAF (0.52) | BRAFRAF1KDRMAPK14CSF1R | |
| SCHEMBL3551325 | 0.85 | BRAF (0.68) | BRAFRAF1KDRMAPK14MET | |
| SCHEMBL3545659 | 0.83 | RAF1 (0.59) | BRAFRAF1KDRMAPK14CSF1R | |
| SCHEMBL4185802 | 0.82 | RAF1 (0.65) | BRAFRAF1KDRMAPK14CSF1R | |
| SCHEMBL3538127 | 0.82 | RAF1 (0.67) | BRAFRAF1KDRMAPK14CSF1R | |
| SCHEMBL3549837 | 0.80 | RAF1 (0.67) | BRAFRAF1KDRMAPK14CSF1R | |
| SCHEMBL3546107 | 0.80 | RAF1 (0.66) | BRAFRAF1KDRMAPK14CSF1R | |
| SCHEMBL3545160 | 0.80 | RAF1 (0.74) | BRAFRAF1KDRMAPK14CSF1R | |
| SCHEMBL3550019 | 0.80 | RAF1 (0.71) | BRAFRAF1KDRMAPK14CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7652041-B2 | 4-[4-(3-oxo-3-{[3-(trifluoromethyl)phenyl]amino}propyl)phenoxy]pyridino-2-carboxamido: N-methyl-4-[4-(3-oxo-3-{[3-(trifluoromethyl)phenyl]amino}propyl)phenoxy]pyridine-2-carboxamide: Raf-kinase inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-01-26 | — | — | US | claimed |
| US-7652041-B2 | 4-[4-(3-oxo-3-{[3-(trifluoromethyl)phenyl]amino}propyl)phenoxy]pyridino-2-carboxamido: N-methyl-4-[4-(3-oxo-3-{[3-(trifluoromethyl)phenyl]amino}propyl)phenoxy]pyridine-2-carboxamide: Raf-kinase inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-01-26 | — | — | US | disclosed |
| US-7652041-B2 | 4-[4-(3-oxo-3-{[3-(trifluoromethyl)phenyl]amino}propyl)phenoxy]pyridino-2-carboxamido: N-methyl-4-[4-(3-oxo-3-{[3-(trifluoromethyl)phenyl]amino}propyl)phenoxy]pyridine-2-carboxamide: Raf-kinase inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-01-26 | — | — | US | disclosed |