Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 5/20 | 0.68 |
| ▸ | BRAF | P15056 | 3/20 | 0.68 |
| ▸ | KDR | P35968 | 7/20 | 0.55 |
| ▸ | FLT1 | P17948 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3545552 | 0.92 | RAF1 (0.69) | RAF1BRAFKDRFLT1HDAC3 | |
| SCHEMBL13547755 | 0.87 | RAF1 (0.66) | RAF1BRAFKDRFLT1HDAC3 | |
| SCHEMBL3545292 | 0.86 | RAF1 (0.67) | RAF1BRAFKDRFLT1HDAC3 | |
| SCHEMBL3543215 | 0.85 | RAF1 (0.67) | RAF1BRAFKDRFLT1HDAC3 | |
| SCHEMBL3549607 | 0.84 | RAF1 (0.66) | RAF1BRAFKDRFLT1HDAC3 | |
| SCHEMBL3539338 | 0.83 | RAF1 (0.65) | RAF1BRAFKDRFLT1HDAC3 | |
| SCHEMBL3539364 | 0.83 | RAF1 (0.74) | RAF1BRAFKDRFLT1HDAC3 | |
| SCHEMBL3542976 | 0.83 | RAF1 (0.82) | RAF1BRAFKDRFLT1HDAC3 | |
| SCHEMBL3539204 | 0.82 | RAF1 (0.81) | RAF1BRAFKDRFLT1HDAC3 | |
| SCHEMBL3545010 | 0.82 | RAF1 (0.73) | RAF1BRAFKDRHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7652041-B2 | 4-[4-(3-oxo-3-{[3-(trifluoromethyl)phenyl]amino}propyl)phenoxy]pyridino-2-carboxamido: N-methyl-4-[4-(3-oxo-3-{[3-(trifluoromethyl)phenyl]amino}propyl)phenoxy]pyridine-2-carboxamide: Raf-kinase inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-01-26 | — | — | US | claimed |
| US-7652041-B2 | 4-[4-(3-oxo-3-{[3-(trifluoromethyl)phenyl]amino}propyl)phenoxy]pyridino-2-carboxamido: N-methyl-4-[4-(3-oxo-3-{[3-(trifluoromethyl)phenyl]amino}propyl)phenoxy]pyridine-2-carboxamide: Raf-kinase inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-01-26 | — | — | US | disclosed |
| US-7652041-B2 | 4-[4-(3-oxo-3-{[3-(trifluoromethyl)phenyl]amino}propyl)phenoxy]pyridino-2-carboxamido: N-methyl-4-[4-(3-oxo-3-{[3-(trifluoromethyl)phenyl]amino}propyl)phenoxy]pyridine-2-carboxamide: Raf-kinase inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-01-26 | — | — | US | disclosed |