Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 13/20 | 0.72 |
| ▸ | HTR2A | P28223 | 7/20 | 0.71 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | CCR1 | P32246 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | NPY1R | P25929 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5346177 | 0.93 | CCR3 (0.70) | CCR3HTR2AALOX15MEN1KMT2A | |
| SCHEMBL6335910 | 0.83 | CCR3 (1.00) | CCR3HTR2AALOX15MEN1KMT2A | |
| SCHEMBL6340084 | 0.82 | CCR3 (0.76) | CCR3HTR2AALOX15MEN1KMT2A | |
| SCHEMBL6339155 | 0.82 | CCR3 (0.87) | CCR3HTR2AALOX15CYP2D6 | |
| SCHEMBL6330906 | 0.80 | CCR3 (0.87) | CCR3HTR2AALOX15MEN1KMT2A | |
| SCHEMBL6339192 | 0.79 | CCR3 (0.83) | CCR3HTR2AALOX15CYP2D6 | |
| SCHEMBL6330741 | 0.79 | CCR3 (0.79) | CCR3HTR2AALOX15MEN1KMT2A | |
| SCHEMBL6331972 | 0.79 | CCR3 (0.84) | CCR3HTR2AALOX15CYP2D6 | |
| SCHEMBL6330950 | 0.79 | CCR3 (0.85) | CCR3HTR2AALOX15 | |
| SCHEMBL5339240 | 0.78 | CCR3 (0.81) | CCR3HTR2AALOX15CCR1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7754758-B2 | Pyrrolidine derivatives acting as CCR3-receptor antagonists | NOVARTIS AG (CH) | 2010-07-13 | — | — | US | disclosed |