Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
| ▸ | ATP1A1 | P05023 | 3/20 | 0.37 |
| ▸ | ATP1B1 | P05026 | 3/20 | 0.37 |
| ▸ | ATP1A3 | P13637 | 3/20 | 0.37 |
| ▸ | ATP1B2 | P14415 | 3/20 | 0.37 |
| ▸ | ATP1A2 | P50993 | 3/20 | 0.37 |
| ▸ | ATP1B3 | P54709 | 3/20 | 0.37 |
| ▸ | FXYD2 | P54710 | 3/20 | 0.37 |
| ▸ | ATP1A4 | Q13733 | 3/20 | 0.37 |
| ▸ | LCK | P06239 | 4/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3554499 | 0.88 | IGF1R (0.39) | TP53SMN1; SMN2IDH1ATP1A1ATP1B1 | |
| SCHEMBL3548594 | 0.88 | MAPK14 (0.40) | TP53SMN1; SMN2IDH1ATP1A1ATP1B1 | |
| SCHEMBL3551921 | 0.88 | TP53 (0.43) | TP53SMN1; SMN2IDH1ATP1A1ATP1B1 | |
| SCHEMBL3555836 | 0.87 | TP53 (0.38) | TP53SMN1; SMN2IDH1ATP1A1ATP1B1 | |
| SCHEMBL3549226 | 0.87 | HDAC6 (0.39) | TP53SMN1; SMN2IDH1ATP1A1ATP1B1 | |
| SCHEMBL3550460 | 0.86 | IGF1R (0.43) | TP53SMN1; SMN2IDH1ATP1A1ATP1B1 | |
| SCHEMBL3551710 | 0.86 | TP53 (0.40) | TP53SMN1; SMN2IDH1ATP1A1ATP1B1 | |
| SCHEMBL3552661 | 0.85 | TP53 (0.43) | TP53SMN1; SMN2IDH1HDAC1HDAC6 | |
| SCHEMBL3550090 | 0.85 | TP53 (0.39) | TP53SMN1; SMN2IDH1ATP1A1ATP1B1 | |
| SCHEMBL3546850 | 0.85 | PLK1 (0.47) | TP53SMN1; SMN2IDH1ATP1A1ATP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7718801-B2 | Substituted imidazole derivative | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2010-05-18 | — | — | US | disclosed |
| US-20080070894-A1 | Novel Substituted Imidazole Derivative | MSD K.K. (JP) | 2008-03-20 | — | — | US | disclosed |
| EP-1790650-A1 | NOVEL SUBSTITUTED IMIDAZOLE DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-05-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080070894-A1 | Novel Substituted Imidazole Derivative | PLK1, CDK1, CDK11A | TP53 238/4885SMN1; SMN2 3452/4885IDH1 767/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.