Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 16/20 | 0.66 |
| ▸ | CDK1 | P06493 | 5/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.60 |
| ▸ | CDK4 | P11802 | 2/20 | 0.59 |
| ▸ | CDKL1 | Q00532 | 1/20 | 0.59 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.56 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.56 |
| ▸ | CCND1 | P24385 | 1/20 | 0.56 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.56 |
| ▸ | CCND3 | P30281 | 1/20 | 0.56 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.56 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.56 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.56 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.56 |
| ▸ | GSK3A | P49840 | 1/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.56 |
| ▸ | CDK7 | P50613 | 1/20 | 0.56 |
| ▸ | CDK9 | P50750 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3551012 | 0.93 | CDK2 (0.64) | CDK2CDK1KCNH2CDK4CDKL1 | |
| SCHEMBL3551552 | 0.93 | KCNH2 (0.67) | CDK2CDK1KCNH2CDK4CDKL1 | |
| SCHEMBL3549598 | 0.88 | CDK2 (0.83) | CDK2CDK1KCNH2CDK4CCNT1 | |
| SCHEMBL3550098 | 0.84 | CDK2 (0.66) | CDK2CDK1KCNH2 | |
| SCHEMBL1448977 | 0.83 | CDK2 (0.77) | CDK2CDK1KCNH2CDK4CCNT1 | |
| SCHEMBL1448454 | 0.81 | CDK2 (0.73) | CDK2CDK1KCNH2CDK4CDKL1 | |
| SCHEMBL1447533 | 0.81 | CDK2 (0.82) | CDK2CDK1KCNH2CDK4CDKL1 | |
| SCHEMBL1448455 | 0.80 | CDK2 (0.75) | CDK2CDK1KCNH2CDK4CCNT1 | |
| SCHEMBL3552047 | 0.80 | CDK2 (0.67) | CDK2CDK1KCNH2 | |
| SCHEMBL1447979 | 0.79 | CDK2 (0.76) | CDK2CDK1KCNH2CDK4CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7655652-B2 | 2-{4-[4-(2-hydroxyacetyl)piperazin-1-yl]anilino}-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-5-fluoropyrimidine hydrochloride; cell cycle inhibitory; rheumatoid arthritis | ASTRAZENECA AB (SE) | 2010-02-02 | — | — | US | disclosed |
| US-20070161615-A1 | Chemical compounds | ASTRAZENECA AB (SE) | 2007-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161615-A1 | Chemical compounds | MKI67, PCNA, CCNI | CDK2 84/4885CDK1 31/4885KCNH2 4616/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.