Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.60 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.60 |
| ▸ | AAK1 | Q2M2I8 | 12/20 | 0.60 |
| ▸ | CIT | O14578 | 1/20 | 0.60 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.60 |
| ▸ | GAK | O14976 | 1/20 | 0.60 |
| ▸ | STK10 | O94804 | 1/20 | 0.60 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.60 |
| ▸ | ABL1 | P00519 | 1/20 | 0.60 |
| ▸ | LCK | P06239 | 1/20 | 0.60 |
| ▸ | FYN | P06241 | 1/20 | 0.60 |
| ▸ | YES1 | P07947 | 1/20 | 0.60 |
| ▸ | LYN | P07948 | 1/20 | 0.60 |
| ▸ | RET | P07949 | 1/20 | 0.60 |
| ▸ | HCK | P08631 | 1/20 | 0.60 |
| ▸ | SRC | P12931 | 1/20 | 0.60 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.60 |
| ▸ | PRKCA | P17252 | 1/20 | 0.60 |
| ▸ | PRKACA | P17612 | 1/20 | 0.60 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4416439 | 1.00 | EGFR (0.60) | EGFRERBB2AAK1CITCHEK1 | |
| SCHEMBL1220131 | 1.00 | EGFR (0.60) | EGFRERBB2AAK1CITCHEK1 | |
| SCHEMBL1220096 | 0.93 | EGFR (0.72) | EGFRERBB2AAK1CITCHEK1 | |
| SCHEMBL1220098 | 0.93 | EGFR (0.72) | EGFRERBB2AAK1CITCHEK1 | |
| SCHEMBL1220101 | 0.93 | EGFR (0.72) | EGFRERBB2AAK1CITCHEK1 | |
| SCHEMBL1219924 | 0.89 | EGFR (0.71) | EGFRERBB2AAK1CITCHEK1 | |
| SCHEMBL1220075 | 0.89 | EGFR (0.71) | EGFRERBB2AAK1CITCHEK1 | |
| SCHEMBL3554356 | 0.89 | EGFR (0.71) | EGFRERBB2AAK1CITCHEK1 | |
| SCHEMBL1219921 | 0.89 | EGFR (0.71) | EGFRERBB2AAK1CITCHEK1 | |
| SCHEMBL4421457 | 0.88 | EGFR (0.74) | EGFRERBB2AAK1CITCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7846931-B2 | Pyrrolotriazine compounds as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-12-07 | — | — | US | disclosed |
| EP-2058314-A1 | Pyrrolotriazine compounds as kinase inhibitors | Bristol-Myers Squibb Company (US) | 2009-05-13 | — | — | EP | disclosed |