Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.40 |
| ▸ | IGF1R | P08069 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.36 |
| ▸ | ATP1A1 | P05023 | 3/20 | 0.35 |
| ▸ | ATP1B1 | P05026 | 3/20 | 0.35 |
| ▸ | ATP1A3 | P13637 | 3/20 | 0.35 |
| ▸ | ATP1B2 | P14415 | 3/20 | 0.35 |
| ▸ | ATP1A2 | P50993 | 3/20 | 0.35 |
| ▸ | ATP1B3 | P54709 | 3/20 | 0.35 |
| ▸ | FXYD2 | P54710 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3550669 | 0.91 | PLK1 (0.48) | PLK1ALDH1A1HPGDRPS6KB1IGF1R | |
| SCHEMBL3554499 | 0.86 | IGF1R (0.39) | RPS6KB1IGF1RSMN1; SMN2NTRK1HDAC3 | |
| SCHEMBL3551540 | 0.85 | IDH1 (0.39) | RPS6KB1IGF1RNTRK1HDAC3HDAC1 | |
| SCHEMBL3546850 | 0.83 | PLK1 (0.47) | PLK1ALDH1A1HPGDRPS6KB1IGF1R | |
| SCHEMBL3556828 | 0.83 | HDAC6 (0.38) | RPS6KB1IGF1RNTRK1HDAC3HDAC1 | |
| SCHEMBL3552664 | 0.83 | HDAC6 (0.42) | IGF1RNTRK1ARHDAC3HDAC1 | |
| SCHEMBL3551701 | 0.83 | HDAC3 (0.39) | RPS6KB1IGF1RNTRK1HDAC3HDAC1 | |
| SCHEMBL3556865 | 0.83 | PLK1 (0.46) | PLK1ALDH1A1HPGDRPS6KB1KDM4E | |
| SCHEMBL3551627 | 0.83 | PLK1 (0.46) | PLK1ALDH1A1HPGDRPS6KB1IGF1R | |
| SCHEMBL3551698 | 0.82 | HDAC3 (0.41) | ALDH1A1IGF1RKDM4ENTRK1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7718801-B2 | Substituted imidazole derivative | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2010-05-18 | — | — | US | disclosed |
| US-20080070894-A1 | Novel Substituted Imidazole Derivative | MSD K.K. (JP) | 2008-03-20 | — | — | US | disclosed |
| EP-1790650-A1 | NOVEL SUBSTITUTED IMIDAZOLE DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-05-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080070894-A1 | Novel Substituted Imidazole Derivative | PLK1, CDK1, CDK11A | PLK1 1/4885ALDH1A1 4349/4885HPGD 4322/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.