Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP8 | Q6V1X1 | 20/20 | 1.00 |
| ▸ | DPP4 | P27487 | 19/20 | 1.00 |
| ▸ | DPP7 | Q9UHL4 | 10/20 | 0.92 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.64 |
| ▸ | FAP | Q12884 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13444771 | 1.00 | DPP8 (1.00) | DPP8DPP4DPP7DPP9FAP | |
| SCHEMBL3551827 | 0.96 | DPP8 (1.00) | DPP8DPP4DPP7DPP9 | |
| SCHEMBL3551824 | 0.96 | DPP8 (1.00) | DPP8DPP4DPP7DPP9 | |
| SCHEMBL13444770 | 0.96 | DPP8 (1.00) | DPP8DPP4DPP7DPP9 | |
| SCHEMBL14523911 | 0.89 | DPP4 (1.00) | DPP8DPP4DPP7DPP9FAP | |
| SCHEMBL3549132 | 0.85 | DPP4 (0.73) | DPP8DPP4DPP7DPP9FAP | |
| SCHEMBL3549124 | 0.85 | DPP4 (0.73) | DPP8DPP4DPP7DPP9FAP | |
| SCHEMBL3549128 | 0.85 | DPP4 (0.73) | DPP8DPP4DPP7DPP9FAP | |
| SCHEMBL3548486 | 0.84 | DPP4 (1.00) | DPP8DPP4DPP7DPP9FAP | |
| SCHEMBL13444767 | 0.84 | DPP4 (1.00) | DPP8DPP4DPP7DPP9FAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7687504-B2 | 1-[3-[2-[2-cyano-(S)-pyrrolidin-1-yl]-2-oxo-ethylamino]-1-oxo-propyl]-4-[bis-(4-fluorophenyl)methyl]piperazine; inhibiting dipeptidyl peptidase IV or for treating Type II diabetes | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2010-03-30 | — | — | US | claimed |
| US-7687504-B2 | 1-[3-[2-[2-cyano-(S)-pyrrolidin-1-yl]-2-oxo-ethylamino]-1-oxo-propyl]-4-[bis-(4-fluorophenyl)methyl]piperazine; inhibiting dipeptidyl peptidase IV or for treating Type II diabetes | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2010-03-30 | — | — | US | disclosed |
| WO-2005087235-A1 | PYRROLIDINE COMPOUNDS | NATIONAL HEALTH RESEARCH INSTITUTES (CN) | 2005-09-22 | — | — | WO | disclosed |