Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.72 |
| ▸ | CTSD | P07339 | 9/20 | 0.72 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3561267 | 0.90 | BACE1 (0.68) | BACE1CTSDBACE2 | |
| SCHEMBL15841679 | 0.88 | BACE1 (0.79) | BACE1CTSDBACE2 | |
| SCHEMBL15841681 | 0.88 | BACE1 (0.79) | BACE1CTSDBACE2 | |
| SCHEMBL15841722 | 0.87 | BACE1 (0.68) | BACE1CTSD | |
| SCHEMBL15841634 | 0.87 | BACE1 (0.68) | BACE1CTSD | |
| SCHEMBL15841721 | 0.87 | BACE1 (0.68) | BACE1CTSD | |
| SCHEMBL15841635 | 0.87 | BACE1 (0.68) | BACE1CTSD | |
| SCHEMBL15841626 | 0.86 | BACE1 (0.78) | BACE1CTSDBACE2 | |
| SCHEMBL15841627 | 0.86 | BACE1 (0.78) | BACE1CTSDBACE2 | |
| SCHEMBL15841717 | 0.85 | BACE1 (0.78) | BACE1CTSDBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7838676-B2 | Beta-secretase modulators and methods of use | AMGEN INC. (US) | 2010-11-23 | — | — | US | disclosed |