Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 17/20 | 1.00 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.64 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.64 |
| ▸ | NCOR1 | O75376 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.59 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.59 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3558366 | 0.83 | HDAC1 (0.71) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL4977035 | 0.79 | HDAC1 (0.67) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL3560644 | 0.79 | HDAC1 (1.00) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL20545558 | 0.77 | HDAC1 (0.83) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL1066743 | 0.76 | HDAC1 (1.00) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL4982506 | 0.75 | HDAC1 (0.60) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL2733350 | 0.75 | HDAC1 (0.80) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL1062267 | 0.75 | HDAC1 (0.72) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL1079301 | 0.74 | MAPT (0.72) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL4979153 | 0.73 | HDAC1 (0.63) | HDAC1HDAC2HDAC3HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7838520-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2010-11-23 | — | — | US | claimed |
| US-7868204-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2011-01-11 | — | — | US | disclosed |
| US-7868204-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2011-01-11 | — | — | US | disclosed |
| US-7838520-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2010-11-23 | — | — | US | disclosed |
| US-7838520-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2010-11-23 | — | — | US | disclosed |
| EP-1590340-B1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC (CA) | 2010-04-07 | — | — | EP | disclosed |
| US-7595343-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2009-09-29 | — | — | US | disclosed |
| WO-2004069823-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE, INC. (CA) | 2004-08-19 | — | — | WO | disclosed |
| WO-2003024448-A2 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE, INC. (CA) | 2003-03-27 | — | — | WO | disclosed |