⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2559278 | 0.76 | — | — | |
| SCHEMBL13897284 | 0.74 | — | — | |
| SCHEMBL343112 | 0.71 | — | — | |
| SCHEMBL71329 | 0.71 | — | — | |
| SCHEMBL23644587 | 0.70 | — | — | |
| SCHEMBL83058 | 0.69 | SMN1; SMN2 (0.46) | — | |
| SCHEMBL13201161 | 0.67 | — | — | |
| SCHEMBL13201155 | 0.67 | — | — | |
| SCHEMBL17211649 | 0.67 | SMN1; SMN2 (0.33) | — | |
| SCHEMBL6311458 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9340532-B2 | Methods and compositions for inhibiting CNKSR1 | PHUSIS THERAPEUTICS, INC. (US) | 2016-05-17 | — | — | US | disclosed |
| CN-105039489-A | Methods to manufacture 1,3-dioxolane nucleosides | UNIV EMORY | 2015-11-11 | — | — | CN | disclosed |
| US-20150307482-A1 | METHODS AND COMPOSITIONS FOR INHIBITING CNKSR1 | PHUSIS THERAPEUTICS, INC. (US) | 2015-10-29 | — | — | US | disclosed |
| US-7713998-B2 | Nitrogenous heterocyclic compound and pharmaceutical use thereof | ONO PHARMACEUTICAL CO., LTD. (JP) | 2010-05-11 | — | — | US | disclosed |
| US-20090082203-A1 | INSECTICIDAL BIS(SUBSTITUTED PHENYL)-1-{[4-(SATURATED HETEROCYCLYL-SUBSTITUTED)PHENYLMETHYL]- (4-PIPERIDYL)}METHANE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2009-03-26 | — | — | US | disclosed |
| US-20090082203-A1 | INSECTICIDAL BIS(SUBSTITUTED PHENYL)-1-{[4-(SATURATED HETEROCYCLYL-SUBSTITUTED)PHENYLMETHYL]- (4-PIPERIDYL)}METHANE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2009-03-26 | — | — | US | disclosed |
| US-20070265308-A1 | Nitrogenous Heterocyclic Compound and Pharmaceutical Use Thereof | ONO PHARMACEUTICAL CO., LTD. (JP) | 2007-11-15 | — | — | US | disclosed |
| US-6887700-B2 | Process for the enzymatic preparation of enantiopure 1, 3-dioxolan-4-one and 1,3-oxathiolan-5-one derivatives | Consortium für elektrochemische Industrie GmbH (DE) | 2005-05-03 | — | — | US | disclosed |
| US-20030143698-A1 | Process for the enzymatic preparation of enantiopure 1, 3-dioxolan-4-one and 1,3-oxathiolan-5-one derivatives | WACKER CHEMIE AG (DE) | 2003-07-31 | — | — | US | disclosed |