Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.77 |
| ▸ | ERBB2 | P04626 | 9/20 | 0.77 |
| ▸ | AAK1 | Q2M2I8 | 11/20 | 0.73 |
| ▸ | LCK | P06239 | 1/20 | 0.66 |
| ▸ | KDR | P35968 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1219493 | 0.87 | EGFR (1.00) | EGFRERBB2AAK1LCKKDR | |
| SCHEMBL1219044 | 0.87 | EGFR (1.00) | EGFRERBB2AAK1LCKKDR | |
| SCHEMBL1220077 | 0.87 | EGFR (1.00) | EGFRERBB2AAK1LCKKDR | |
| SCHEMBL1218844 | 0.87 | EGFR (1.00) | EGFRERBB2AAK1LCKKDR | |
| SCHEMBL1219490 | 0.86 | ERBB2 (1.00) | EGFRERBB2AAK1LCKKDR | |
| SCHEMBL1219940 | 0.85 | AAK1 (0.78) | EGFRERBB2AAK1LCKKDR | |
| SCHEMBL1218830 | 0.85 | EGFR (0.75) | EGFRERBB2AAK1LCKKDR | |
| SCHEMBL1218596 | 0.84 | EGFR (1.00) | EGFRERBB2AAK1LCKKDR | |
| SCHEMBL1220015 | 0.84 | EGFR (0.79) | EGFRERBB2AAK1LCKKDR | |
| SCHEMBL1220498 | 0.84 | EGFR (0.78) | EGFRERBB2AAK1LCKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7846931-B2 | Pyrrolotriazine compounds as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-12-07 | — | — | US | disclosed |
| EP-2058314-A1 | Pyrrolotriazine compounds as kinase inhibitors | Bristol-Myers Squibb Company (US) | 2009-05-13 | — | — | EP | disclosed |
| US-20090048244-A1 | PYRROLOTRIAZINE COMPOUNDS AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048244-A1 | PYRROLOTRIAZINE COMPOUNDS AS KINASE INHIBITORS | ERBB2, ERBB4, ERBB3 | EGFR 4/4885ERBB2 1/4885AAK1 123/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.