Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.66 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.66 |
| ▸ | LCK | P06239 | 3/20 | 0.66 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.66 |
| ▸ | PRKCA | P17252 | 2/20 | 0.66 |
| ▸ | PRKCI | P41743 | 2/20 | 0.66 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.66 |
| ▸ | CIT | O14578 | 1/20 | 0.66 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.66 |
| ▸ | GAK | O14976 | 1/20 | 0.66 |
| ▸ | STK10 | O94804 | 1/20 | 0.66 |
| ▸ | ABL1 | P00519 | 1/20 | 0.66 |
| ▸ | FYN | P06241 | 1/20 | 0.66 |
| ▸ | YES1 | P07947 | 1/20 | 0.66 |
| ▸ | LYN | P07948 | 1/20 | 0.66 |
| ▸ | RET | P07949 | 1/20 | 0.66 |
| ▸ | HCK | P08631 | 1/20 | 0.66 |
| ▸ | SRC | P12931 | 1/20 | 0.66 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.66 |
| ▸ | PRKACA | P17612 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3558680 | 1.00 | EGFR (0.66) | EGFRAAK1LCKPRKD3PRKCA | |
| SCHEMBL1219694 | 0.89 | EGFR (0.69) | EGFRAAK1LCKPRKD3PRKCA | |
| SCHEMBL1220446 | 0.89 | EGFR (0.70) | EGFRAAK1LCKPRKD3PRKCA | |
| SCHEMBL1220354 | 0.89 | EGFR (0.78) | EGFRAAK1LCKPRKD3PRKCA | |
| SCHEMBL3626341 | 0.89 | EGFR (0.70) | EGFRAAK1LCKPRKD3PRKCA | |
| SCHEMBL1218652 | 0.89 | EGFR (0.78) | EGFRAAK1LCKPRKD3PRKCA | |
| SCHEMBL1220089 | 0.89 | EGFR (0.70) | EGFRAAK1LCKPRKD3PRKCA | |
| SCHEMBL1220282 | 0.89 | EGFR (0.78) | EGFRAAK1LCKPRKD3PRKCA | |
| SCHEMBL1220160 | 0.89 | EGFR (0.78) | EGFRAAK1LCKPRKD3PRKCA | |
| SCHEMBL1218658 | 0.88 | ERBB2 (0.77) | EGFRAAK1LCKPRKD3PRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7846931-B2 | Pyrrolotriazine compounds as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-12-07 | — | — | US | disclosed |