⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27512900 | 0.97 | — | — | |
| SCHEMBL28416504 | 0.71 | — | — | |
| SCHEMBL444155 | 0.67 | — | — | |
| SCHEMBL3176188 | 0.67 | — | — | |
| SCHEMBL28247868 | 0.67 | — | — | |
| SCHEMBL28242392 | 0.67 | — | — | |
| Ammonia Solution, Strong SCHEMBL29574382 | 0.65 | — | — | |
| Ethane SCHEMBL27619247 | 0.65 | — | — | |
| SCHEMBL10799347 | 0.64 | — | — | |
| SCHEMBL11062500 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103936690-B | Aminodihydrothiazine derivatives | 盐野义制药株式会社 | 2016-06-08 | — | — | CN | disclosed |
| EP-2597087-B1 | Dihydrooxazine and tetrahydropyrimidine derivatives as BACE 1 inhibitors | SHIONOGI & CO (JP) | 2016-03-30 | — | — | EP | disclosed |
| US-20150210680-A1 | AMINODIHYDROTHIAZINE DERIVATIVES | SHIONOGI & CO (JP) | 2015-07-30 | — | — | US | disclosed |
| US-9029358-B2 | Aminodihydrothiazine derivatives | SHIONOGI & CO., LTD. (JP) | 2015-05-12 | — | — | US | disclosed |
| EP-2612854-B1 | Aminothiazolidine and aminotetrahydrothiazepine derivatives as BACE 1 inhibitors | SHIONOGI & CO (JP) | 2015-04-29 | — | — | EP | disclosed |
| US-8895548-B2 | Pharmaceutical composition for treating alzheimer's disease | SHIONOGI & CO., LTD. (JP) | 2014-11-25 | — | — | US | disclosed |
| US-8815851-B2 | Aminodihydrothiazine derivatives | SHIONOGI & CO., LTD. (JP) | 2014-08-26 | — | — | US | disclosed |
| CN-103936690-A | Aminodihydrothiazine derivatives | SHIONOGI & CO | 2014-07-23 | — | — | CN | disclosed |
| EP-1942105-B1 | AMINODIHYDROTHIAZINE DERIVATIVE | SHIONOGI & CO (JP) | 2014-04-16 | — | — | EP | disclosed |
| CN-101346357-B | Aminodihydrothiazine derivatives | SHIONOGI & CO | 2014-04-02 | — | — | CN | disclosed |
| CN-101346357-A | Aminodihydrothiazine derivatives | SHIONOGI & CO (JP) | 2009-01-14 | — | — | CN | disclosed |
| EP-1942105-A1 | AMINODIHYDROTHIAZINE DERIVATIVE | Shionogi Co., Ltd. (JP) | 2008-07-09 | — | — | EP | disclosed |
| CN-1738817-A | Novel antagonist derivatives of vitronectin receptors, process for their preparation, their use as medicaments and pharmaceutical compositions containing them | PROSKELIA SAS (FR) | 2006-02-22 | — | — | CN | disclosed |
| EP-1282621-B1 | VITRONECTIN RECEPTOR ANTAGONISTS | AVENTIS PHARMA SA (FR) | 2005-09-07 | — | — | EP | disclosed |
| US-6838453-B2 | Antagonist derivatives of the vitronectin receptor | AVENTIS PHARMA S.A. (FR) | 2005-01-04 | — | — | US | disclosed |
| US-20040225111-A1 | ANTAGONIST DERIVATIVES OF THE VITRONECTIN RECEPTOR | AVENTIS PHARMA S.A. (FR) | 2004-11-11 | — | — | US | disclosed |
| EP-1282621-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | Aventis Pharma S.A. (FR) | 2003-02-12 | — | — | EP | disclosed |
| WO-2001085729-A1 | NOVEL VITRONECTIN RECEPTOR ANTAGONISTS | AVENTIS PHARMA S.A. (FR) | 2001-11-15 | — | — | WO | disclosed |
| US-4322421-A | 4-Phenyl-and 5-phenyl-1,4,5,6-tetrahydro-pyrimidine derivatives | SYNTEX (U.S.A.) INC. (US) | 1982-03-30 | — | — | US | disclosed |
| US-4261995-A | DISORDERS OF CENTRAL NERVOUS SYSTEM AND CARDIOVASCULAR SYSTEM; HYPOTENSIVE | SYNTEX (U.S.A.) INC. (US) | 1981-04-14 | — | — | US | disclosed |