⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9723481 | 0.78 | TSHR (0.32) | — | |
| SCHEMBL5388818 | 0.76 | — | — | |
| Ammonia Solution, Strong SCHEMBL7558753 | 0.73 | TSHR (0.32) | — | |
| SCHEMBL10297559 | 0.72 | — | — | |
| SCHEMBL7128934 | 0.72 | — | — | |
| SCHEMBL204256 | 0.70 | — | — | |
| SCHEMBL8149485 | 0.69 | — | — | |
| SCHEMBL30552549 | 0.67 | — | — | |
| SCHEMBL29064564 | 0.67 | — | — | |
| SCHEMBL10544628 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7834176-B2 | Polymorph E of Olanzapine and preparation of anhydrous non-solvated crystalline polymorphic Form I of 2-methyl-4(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine (Olanzapine Form I) from the polymorphic Olanzapine Form E | SANDOZ AG (CH) | 2010-11-16 | — | — | US | disclosed |
| WO-2007087555-A2 | NOVEL POLYMORPH 'FORM E ' OF OLANZAPINE (2-METHYL-4- (4-METHYL-1-PIPERAZINYL) -10H-THIENO [2, 3-B] [1, 5] BENZODIAZEPINE) AND PREPARATION OF THE ANHYDROUS NON-SOLVATED CRYSTALLINE POLYMORPHIC 'FORM I' OF OLANZAPINE FROM THE POLYMORPHIC OLANZAPINE 'FORM E' | SANDOZ AG (CH) | 2007-08-02 | — | — | WO | disclosed |
| US-20070173496-A1 | Novel polymorph E of Olanzapine and preparation of anhydrous non-solvated crystalline polymorphic Form I of 2-methyl-4(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine (Olanzapine Form I) from the polymorphic Olanzapine Form E | SANDOZ AG (CH) | 2007-07-26 | — | — | US | disclosed |
| US-4482739-A | INTERMEDIATES FOR ANTIANDROGENS AND PARASITICIDES | HOFFMANN-LA ROCHE INC. (US) | 1984-11-13 | — | — | US | disclosed |
| US-4407814-A | ANTIANDROGENS, 3-(HALO- AND/OR TRIFULOROMETHYL-PHENYL)-4,4-DIMETHYL-HYDANTOINS AND IMINO DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 1983-10-04 | — | — | US | disclosed |