Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYBB | P04839 | 2/20 | 0.59 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.59 |
| ▸ | PIM1 | P11309 | 13/20 | 0.57 |
| ▸ | PIM2 | Q9P1W9 | 9/20 | 0.57 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.46 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13500717 | 0.89 | CYBB (0.61) | CYBBSLC2A1PIM1PIM2FLT3 | |
| SCHEMBL13500787 | 0.86 | SLC2A1 (0.72) | CYBBSLC2A1PIM1PIM2FLT3 | |
| SCHEMBL17085461 | 0.86 | FYN (0.50) | CYBBSLC2A1PIM1PIM2CAMKK1 | |
| SCHEMBL20723060 | 0.85 | PIM1 (0.52) | CYBBSLC2A1PIM1PIM2KDR | |
| SCHEMBL13500813 | 0.85 | SLC2A1 (0.70) | CYBBSLC2A1PIM1PIM2FLT3 | |
| SCHEMBL13500843 | 0.84 | CYBB (0.69) | CYBBSLC2A1PIM1PIM2JAK2 | |
| SCHEMBL13501074 | 0.84 | SLC2A1 (0.72) | CYBBSLC2A1PIM1PIM2FLT3 | |
| SCHEMBL13500815 | 0.84 | SLC2A1 (0.75) | CYBBSLC2A1PIM1PIM2FLT3 | |
| SCHEMBL13500791 | 0.83 | CYBB (0.70) | CYBBSLC2A1PIM1PIM2JAK2 | |
| SCHEMBL3562267 | 0.83 | CYBB (0.54) | CYBBSLC2A1PIM1PIM2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7662826-B2 | Pyrazolo [1,5-a] pyrimidine derivative and nad (p) h oxidase inhibitor containing the same | SHIONOGI & CO., LTD. (JP) | 2010-02-16 | — | — | US | disclosed |
| US-7662826-B2 | Pyrazolo [1,5-a] pyrimidine derivative and nad (p) h oxidase inhibitor containing the same | SHIONOGI & CO., LTD. (JP) | 2010-02-16 | — | — | US | disclosed |
| US-7662826-B2 | Pyrazolo [1,5-a] pyrimidine derivative and nad (p) h oxidase inhibitor containing the same | SHIONOGI & CO., LTD. (JP) | 2010-02-16 | — | — | US | disclosed |
| US-20060089362-A1 | Pyrazolo [1,5-a] pyrimidine derivative and nad (p) h oxidase inhibitor containing the same | SHIONOGI & CO., LTD (JP) | 2006-04-27 | — | — | US | disclosed |
| EP-1505068-A1 | PYRAZOLO (1,5-a) PYRIMIDINE DERIVATIVE AND NAD(P)H OXIDASE INHIBITOR CONTAINING THE SAME | SHIONOGI & CO., LTD. (JP) | 2005-02-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060089362-A1 | Pyrazolo [1,5-a] pyrimidine derivative and nad (p) h oxidase inhibitor containing the same | NADK, PNPO, NQO1 | CYBB 21/4885SLC2A1 2073/4885PIM1 2270/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.