Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 8/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2655726 | 1.00 | GCK (0.70) | GCKALDH1A1HSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL3562541 | 0.92 | GCK (0.71) | GCKALDH1A1HSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL2655003 | 0.92 | GCK (0.71) | GCKALDH1A1HSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL2654734 | 0.90 | GCK (0.69) | GCKALDH1A1HSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL2654741 | 0.90 | GCK (0.69) | GCKALDH1A1HSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL2655854 | 0.89 | GCK (0.72) | GCKALDH1A1HSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL3566833 | 0.89 | GCK (0.72) | GCKALDH1A1HSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL2656073 | 0.87 | GCK (0.67) | GCKALDH1A1HSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL3562913 | 0.87 | GCK (0.67) | GCKALDH1A1HSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL3560511 | 0.87 | GCK (0.67) | GCKALDH1A1HSD17B10SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7795257-B2 | Organic compounds | NOVARTIS AG (CH) | 2010-09-14 | — | — | US | claimed |
| US-20080318948-A1 | Organic Compounds | NOVARTIS AG (CH) | 2008-12-25 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318948-A1 | Organic Compounds | GCK, GCKR, SLC2A2 | GCK 1/4885ALDH1A1 236/4885HSD17B10 250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.