Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 7/20 | 0.70 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.70 |
| ▸ | STS | P08842 | 4/20 | 0.70 |
| ▸ | LMNA | P02545 | 3/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.70 |
| ▸ | TSHR | P16473 | 2/20 | 0.70 |
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.70 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.70 |
| ▸ | SHBG | P04278 | 2/20 | 0.70 |
| ▸ | PGR | P06401 | 2/20 | 0.70 |
| ▸ | AR | P10275 | 2/20 | 0.70 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.70 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.70 |
| ▸ | HTR2B | P41595 | 2/20 | 0.70 |
| ▸ | SULT1A1 | P50225 | 2/20 | 0.70 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.70 |
| ▸ | AOX1 | Q06278 | 2/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1447387 | 1.00 | ESR1 (0.70) | ESR1ESR2HSD17B10STSLMNA | |
| SCHEMBL11051798 | 0.87 | ESR1 (0.68) | ESR1ESR2HSD17B10STSLMNA | |
| Estradiol SCHEMBL18258335 | 0.83 | ESR1 (1.00) | ESR1ESR2HSD17B10STSLMNA | |
| Estradiol SCHEMBL19217062 | 0.83 | ESR1 (1.00) | ESR1ESR2HSD17B10STSLMNA | |
| Estradiol SCHEMBL7260525 | 0.83 | ESR1 (1.00) | ESR1ESR2HSD17B10STSLMNA | |
| Estradiol SCHEMBL24037697 | 0.83 | ESR1 (1.00) | ESR1ESR2HSD17B10STSLMNA | |
| Estradiol SCHEMBL15610524 | 0.83 | ESR1 (1.00) | ESR1ESR2HSD17B10STSLMNA | |
| Estradiol SCHEMBL10039358 | 0.83 | ESR1 (1.00) | ESR1ESR2HSD17B10STSLMNA | |
| Estradiol SCHEMBL7037626 | 0.83 | ESR1 (1.00) | ESR1ESR2HSD17B10STSLMNA | |
| Estradiol SCHEMBL15610005 | 0.83 | ESR1 (1.00) | ESR1ESR2HSD17B10STSLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120015917-A1 | Use of Estrogenic Compounds in Combination with Progestogenic Compounds in Hormone-Replacement Therapy | PANTARHEI BIOSCIENCE B.V. (NL) | 2012-01-19 | — | — | US | disclosed |