Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.79 |
| ▸ | CTSD | P07339 | 14/20 | 0.79 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3591509 | 1.00 | BACE1 (0.79) | BACE1CTSDBACE2 | |
| SCHEMBL2177200 | 0.87 | BACE1 (0.59) | BACE1CTSDBACE2 | |
| SCHEMBL2174971 | 0.80 | BACE1 (0.87) | BACE1CTSDBACE2 | |
| SCHEMBL3580454 | 0.80 | BACE1 (0.84) | BACE1CTSDBACE2 | |
| SCHEMBL2174966 | 0.80 | BACE1 (0.87) | BACE1CTSDBACE2 | |
| SCHEMBL3580452 | 0.80 | BACE1 (0.84) | BACE1CTSDBACE2 | |
| SCHEMBL3574018 | 0.80 | BACE1 (0.84) | BACE1CTSDBACE2 | |
| SCHEMBL3574021 | 0.80 | BACE1 (0.84) | BACE1CTSDBACE2 | |
| SCHEMBL2175125 | 0.79 | BACE1 (0.88) | BACE1CTSDBACE2 | |
| SCHEMBL2175129 | 0.79 | BACE1 (0.88) | BACE1CTSDBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745484-B2 | Beta-secretase modulators and methods of use | AMGEN INC. (US) | 2010-06-29 | — | — | US | claimed |