Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.48 |
| ▸ | GRM1 | Q13255 | 6/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NR0B1 | P51843 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13166125 | 1.00 | MEN1 (0.51) | MEN1KMT2AGAAPOLBMAPK10 | |
| SCHEMBL3352571 | 0.89 | MEN1 (0.55) | MEN1KMT2AGAAPOLBMAPK10 | |
| SCHEMBL13166096 | 0.89 | MEN1 (0.55) | MEN1KMT2AGAAPOLBMAPK10 | |
| SCHEMBL13166118 | 0.89 | MEN1 (0.51) | MEN1KMT2AGAAPOLBMAPK10 | |
| SCHEMBL3347847 | 0.89 | MEN1 (0.51) | MEN1KMT2AGAAPOLBMAPK10 | |
| SCHEMBL13166223 | 0.86 | MEN1 (0.51) | MEN1KMT2AGAAPOLBMAPK10 | |
| SCHEMBL3355015 | 0.86 | MEN1 (0.51) | MEN1KMT2AGAAPOLBMAPK10 | |
| SCHEMBL3357242 | 0.84 | MEN1 (0.50) | MEN1KMT2AGAAPOLBMAPK10 | |
| SCHEMBL13166226 | 0.84 | MEN1 (0.50) | MEN1KMT2AGAAPOLBMAPK10 | |
| SCHEMBL3350983 | 0.84 | MEN1 (0.67) | MEN1KMT2AGAAPOLBTGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803945-B2 | Tetrahydropyridothiophenes | 4SC AG (DE) | 2010-09-28 | — | — | US | claimed |
| EP-1753512-B1 | TETRAHYDROPYRIDOTHIOPHENES | NYCOMED GMBH (DE) | 2008-07-09 | — | — | EP | claimed |
| EP-1753512-B1 | TETRAHYDROPYRIDOTHIOPHENES | NYCOMED GMBH (DE) | 2008-07-09 | — | — | EP | disclosed |
| EP-1753512-A2 | TETRAHYDROPYRIDOTHIOPHENES | Altana Pharma AG (DE) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005118071-A2 | TETRAHYDROPYRIDOTHIOPHENES | ALTANA PHARMA AG (DE) | 2005-12-15 | — | — | WO | disclosed |