Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHPS | P49366 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.44 |
| ▸ | USP36 | Q9P275 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.43 |
| ▸ | PRSS12 | P56730 | 3/20 | 0.43 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3575556 | 0.91 | HDAC2 (0.50) | DHPSHDAC2HDAC3HDAC1PRSS12 | |
| SCHEMBL3579179 | 0.91 | HDAC2 (0.51) | DHPSHDAC2HDAC3HDAC1NCOR2 | |
| SCHEMBL3561534 | 0.90 | HDAC2 (0.45) | DHPSHDAC2HDAC3HDAC1GPR139 | |
| SCHEMBL3570589 | 0.84 | HDAC1 (0.55) | HDAC2HDAC3HDAC1NCOR2 | |
| SCHEMBL3568753 | 0.80 | HDAC2 (0.53) | DHPSHDAC2HDAC1PRSS12 | |
| SCHEMBL3575528 | 0.80 | HDAC2 (0.62) | DHPSHDAC2HDAC3HDAC1PRSS12 | |
| SCHEMBL3815504 | 0.78 | HDAC3 (0.55) | DHPSHDAC2HDAC3HDAC1PRSS12 | |
| SCHEMBL3563743 | 0.77 | HDAC2 (0.54) | HDAC2HDAC3HDAC1NCOR2 | |
| SCHEMBL3566830 | 0.75 | HDAC1 (0.51) | HDAC2HDAC3HDAC1MEN1KMT2A | |
| SCHEMBL3577453 | 0.75 | HDAC2 (0.47) | DHPSHDAC2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090082308-A1 | Benzothiophene derivatives | MERCK SHARP & DOHME LLC | 2009-03-26 | — | — | US | claimed |
| US-7834034-B2 | Benzothiophene derivatives | MERCK SHARP & DOHME CORP. (US) | 2010-11-16 | — | — | US | disclosed |
| US-20090082308-A1 | Benzothiophene derivatives | MERCK SHARP & DOHME LLC | 2009-03-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090082308-A1 | Benzothiophene derivatives | BRDT, HDAC5, BRPF3 | DHPS 1987/4885HDAC2 8/4885USP36 1023/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.