Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 17/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 16/20 | 0.54 |
| ▸ | TRAP1 | Q12931 | 4/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.54 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3574110 | 0.89 | HSP90AA1 (0.42) | HSP90AB1HSP90AA1TRAP1ERBB2HSP90B1 | |
| SCHEMBL10314817 | 0.88 | HSP90AB1 (0.63) | HSP90AB1HSP90AA1TRAP1ERBB2HSP90B1 | |
| SCHEMBL3580145 | 0.87 | HSP90AB1 (0.58) | HSP90AB1HSP90AA1TRAP1ERBB2HSP90B1 | |
| SCHEMBL10314816 | 0.87 | HSP90AB1 (0.58) | HSP90AB1HSP90AA1TRAP1ERBB2HSP90B1 | |
| SCHEMBL3576577 | 0.81 | HSP90AB1 (0.61) | HSP90AB1HSP90AA1TRAP1ERBB2HSP90B1 | |
| SCHEMBL3576580 | 0.81 | HSP90AB1 (0.61) | HSP90AB1HSP90AA1TRAP1ERBB2HSP90B1 | |
| SCHEMBL3576675 | 0.81 | HSP90AB1 (0.61) | HSP90AB1HSP90AA1TRAP1ERBB2HSP90B1 | |
| SCHEMBL3570705 | 0.81 | HSP90AA1 (0.48) | HSP90AB1HSP90AA1ERBB2HDAC3HDAC4 | |
| SCHEMBL3580901 | 0.80 | HSP90AA1 (0.63) | HSP90AB1HSP90AA1TRAP1ERBB2HSP90B1 | |
| SCHEMBL3580904 | 0.80 | HSP90AA1 (0.63) | HSP90AB1HSP90AA1TRAP1ERBB2HSP90B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8217050-B2 | Adenine derivative as inhibitors of HSP90 for the treatment of cancer | CHROMA THERAPEUTICS LIMITED (GB) | 2012-07-10 | — | — | US | disclosed |
| US-20100035901-A1 | ADENINE DERIVATIVE AS INHIBITORS OF HSP90 FOR THE TREATMENT OF CANCER | CHROMA THERAPEUTICS LTD. | 2010-02-11 | — | — | US | disclosed |
| EP-2084161-A1 | ADENINE DERIVATIVES AS INHIBITORS OF HSP90 FOR THE TREATMENT OF CANCER | Chroma Therapeutics Limited (GB) | 2009-08-05 | — | — | EP | disclosed |
| WO-2008056120-A1 | ADENINE DERIVATIVES AS INHIBITORS OF HSP90 FOR THE TREATMENT OF CANCER | CHROMA THERAPEUTICS LTD (GB) | 2008-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035901-A1 | ADENINE DERIVATIVE AS INHIBITORS OF HSP90 FOR THE TREATMENT OF CANCER | HSP90AA1, HSP90AB1, HSP90B1 | HSP90AB1 2/4885HSP90AA1 1/4885TRAP1 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.