Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.50 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | STAT3 | P40763 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NR0B1 | P51843 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4603733 | 0.93 | MEN1 (0.50) | MEN1KMT2APOLBGAATGFBR1 | |
| SCHEMBL13166105 | 0.91 | STAT3 (0.51) | MEN1KMT2APOLBGAATGFBR1 | |
| SCHEMBL3354670 | 0.91 | STAT3 (0.51) | MEN1KMT2APOLBGAATGFBR1 | |
| SCHEMBL3353217 | 0.90 | MEN1 (0.49) | MEN1KMT2APOLBGAATGFBR1 | |
| SCHEMBL13166318 | 0.90 | MEN1 (0.49) | MEN1KMT2APOLBGAATGFBR1 | |
| SCHEMBL3565780 | 0.90 | MEN1 (0.59) | MEN1KMT2APOLBGAATGFBR1 | |
| SCHEMBL3351584 | 0.89 | MEN1 (0.49) | MEN1KMT2APOLBGAATGFBR1 | |
| SCHEMBL4604556 | 0.89 | MEN1 (0.49) | MEN1KMT2APOLBGAATGFBR1 | |
| SCHEMBL13166108 | 0.89 | MEN1 (0.49) | MEN1KMT2APOLBGAATGFBR1 | |
| SCHEMBL3352760 | 0.89 | MEN1 (0.52) | MEN1KMT2APOLBGAATGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753512-B1 | TETRAHYDROPYRIDOTHIOPHENES | NYCOMED GMBH (DE) | 2008-07-09 | — | — | EP | claimed |
| US-7803945-B2 | Tetrahydropyridothiophenes | 4SC AG (DE) | 2010-09-28 | — | — | US | disclosed |