Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 6/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 17/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.46 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3574536 | 0.85 | HDAC2 (0.51) | HDAC2HDAC1HDAC3NCOR2 | |
| SCHEMBL3565708 | 0.85 | HDAC1 (0.71) | HDAC2HDAC1HDAC3NCOR2HDAC4 | |
| SCHEMBL3571690 | 0.85 | HDAC2 (0.48) | HDAC2HDAC1HDAC3NCOR2HDAC4 | |
| SCHEMBL13074150 | 0.84 | HDAC2 (0.61) | HDAC2HDAC1HDAC3 | |
| SCHEMBL3566001 | 0.83 | HDAC2 (0.49) | HDAC2HDAC1 | |
| SCHEMBL3565292 | 0.83 | HDAC1 (0.46) | HDAC2HDAC1HDAC3NCOR2 | |
| SCHEMBL3568743 | 0.83 | HDAC2 (0.66) | HDAC2HDAC1HDAC3NCOR2HDAC4 | |
| SCHEMBL3572237 | 0.81 | HDAC1 (0.73) | HDAC2HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL3575136 | 0.81 | HDAC1 (0.67) | HDAC2HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL3571336 | 0.81 | HDAC1 (0.58) | HDAC2HDAC1HDAC3NCOR2HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7834034-B2 | Benzothiophene derivatives | MERCK SHARP & DOHME CORP. (US) | 2010-11-16 | — | — | US | disclosed |