Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 17/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654525 | 1.00 | GCK (0.65) | GCKKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL3558404 | 0.91 | GCK (0.65) | GCK | |
| SCHEMBL2655361 | 0.91 | GCK (0.65) | GCK | |
| SCHEMBL2648485 | 0.85 | GCK (0.71) | GCKNPC1GAARAB9ASMN1; SMN2 | |
| SCHEMBL2648488 | 0.85 | GCK (0.71) | GCKNPC1GAARAB9ASMN1; SMN2 | |
| SCHEMBL27748425 | 0.85 | GCK (0.57) | GCKKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL2657715 | 0.84 | GCK (0.68) | GCKALDH1A1 | |
| SCHEMBL3569078 | 0.84 | GCK (0.68) | GCKALDH1A1 | |
| SCHEMBL3570329 | 0.83 | GCK (0.64) | GCKKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL2657205 | 0.83 | GCK (0.64) | GCKKDM4EMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7795257-B2 | Organic compounds | NOVARTIS AG (CH) | 2010-09-14 | — | — | US | claimed |
| US-20080318948-A1 | Organic Compounds | NOVARTIS AG (CH) | 2008-12-25 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318948-A1 | Organic Compounds | GCK, GCKR, SLC2A2 | GCK 1/4885KDM4E 1660/4885MEN1 4553/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.