⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28321756 | 0.76 | — | — | |
| SCHEMBL11375024 | 0.76 | — | — | |
| SCHEMBL11064163 | 0.73 | — | — | |
| SCHEMBL27579909 | 0.73 | — | — | |
| SCHEMBL9131757 | 0.70 | — | — | |
| SCHEMBL124148 | 0.67 | — | — | |
| SCHEMBL23452016 | 0.67 | — | — | |
| SCHEMBL10877897 | 0.67 | — | — | |
| SCHEMBL11877968 | 0.67 | — | — | |
| SCHEMBL8333139 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 119 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102757422-B | The derivative of N-[(1H-pyrazol-1-yl) aryl]-1H-indoles or 1H-indazole-3-methane amide, its preparation method and application in the treatment thereof | SAI NUOFEI (FR) | 2015-09-16 | — | — | CN | claimed |
| EP-2702056-A1 | DERIVATIVES OF N- [(1H-PYRAZOL-1-YL) ARYL]- 1H - INDOLE OR 1H - INDAZOLE - 3 - CARBOXAMIDE, THEIR PREPARATION AND THEIR USE AS P2Y12 ANTAGONISTS | Sanofi (FR) | 2014-03-05 | — | — | EP | claimed |
| EP-2518067-B1 | DERIVATIVES OF N-[(1H-PYRAZOL-1-YL)ARYL]-1H-INDOLE OR 1H- INDAZOLE-3-CARBOXAMIDE AND THEIR THERAPEUTIC USES AS P2Y12 ANTAGONISTS | SANOFI SA (FR) | 2014-03-05 | — | — | EP | claimed |
| CN-103619834-A | Derivatives of N-[(1H-pyrazol-1-yl)aryl]-1H-indole or 1H-indazole-3-carboxamide, their preparation and their use as P2Y12 antagonists | SANOFI SA | 2014-03-05 | — | — | CN | claimed |
| EP-2507308-B1 | HYDROLYTICALLY STABLE MULTI-PURPOSE POLYMERS | LUBRIZOL ADVANCED MAT INC (US) | 2014-02-12 | — | — | EP | claimed |
| US-8623862-B2 | Derivatives of N-[(1H-pyrazol-1-yl)aryl]-1H-indole or 1H-indazole-3-carboxamide, preparation thereof and applications thereof in therapeutics | SANOFI (FR) | 2014-01-07 | — | — | US | claimed |
| WO-2012146318-A1 | DERIVATIVES OF N- [(1H-PYRAZOL-1-YL) ARYL] - 1H - INDOLE OR 1H - INDAZOLE - 3 - CARBOXAMIDE, THEIR PREPARATION AND THEIR USE AS P2Y12 ANTAGONISTS | SANOFI (FR) | 2012-11-01 | — | — | WO | claimed |
| US-20120277205-A1 | DERIVATIVES OF N-[(1H-PYRAZOL-1-YL)ARYL]-1H-INDOLE OR 1H-INDAZOLE-3-CARBOXAMIDE, PREPARATION THEREOF AND APPLICATIONS THEREOF IN THERAPEUTICS | SANOFI (FR) | 2012-11-01 | — | — | US | claimed |
| EP-2518067-A1 | Derivatives of N-[(1H-pyrazol-1-YL)aryl]-1H-indole or 1H- indazole-3-carboxamide and their therapeutic uses as P2Y12 antagonists | SANOFI (FR) | 2012-10-31 | — | — | EP | claimed |
| CN-102757422-A | Derivatives of N-[(1H-pyrazol-1-yl)aryl]-1H-indole or 1H- indazole-3-carboxamide and their therapeutic uses as p2y12 antagonists | SANOFI SA | 2012-10-31 | — | — | CN | claimed |
| US-7301028-B2 | Mitotic kinesin inhibitors | MERCK & CO., INC. (US) | 2007-11-27 | — | — | US | claimed |
| EP-1515949-B1 | MITOTIC KINESIN INHIBITORS | MERCK & CO INC (US) | 2007-03-14 | — | — | EP | claimed |
| US-20060063942-A1 | Mitotic kinesin inhibitors | MERCK SHARP & DOHME CORP. | 2006-03-23 | — | — | US | claimed |
| EP-1515949-A4 | MITOTIC KINESIN INHIBITORS | MERCK & CO INC (US) | 2005-11-09 | — | — | EP | claimed |
| EP-1515949-A1 | MITOTIC KINESIN INHIBITORS | Merck & Co., Inc. (US) | 2005-03-23 | — | — | EP | claimed |
| WO-2003106417-A1 | MITOTIC KINESIN INHIBITORS | MERCK & CO., INC. (US) | 2003-12-24 | — | — | WO | claimed |
| WO-1994010142-A1 | NEW SUBSTITUTED AZETIDINONES AS ANTI-INFLAMMATORY AND ANTIDEGENERATIVE AGENTS | MERCK & CO., INC. (US) | 1994-05-11 | — | — | WO | claimed |
| EP-3782986-B1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICALS CO (JP) | 2024-07-10 | — | — | EP | disclosed |
| EP-0033965-A2 | New cephem compounds and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-08-19 | — | — | EP | disclosed |
| US-3959272-A | ANALGESICS, ANTIINFLAMMATORY, PSYCHOTROPIC | SOCIETE ANONYME DITE: HEXACHIME (FR) | 1976-05-25 | — | — | US | disclosed |