SCHEMBL3575263

SCHEMBL3575263

O=C(O)C1CCCc2sc(-c3ccc(OCCCCl)cc3)nc21

nearest known ligand 0.47

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 16/20 0.47
PPARD Q03181 13/20 0.47
FFAR4 Q5NUL3 1/20 0.37
PPARG P37231 3/20 0.36
HDAC1 Q13547 2/20 0.36
HDAC2 Q92769 2/20 0.36
HRH3 Q9Y5N1 1/20 0.36
HDAC6 Q9UBN7 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3578704 0.94 PPARA (0.44) PPARAPPARDPPARGHDAC1HDAC2
SCHEMBL3584501 0.87 PPARA (0.42) PPARAPPARDPPARGHRH3
SCHEMBL3580295 0.85 PPARA (0.46) PPARAPPARDPPARGHDAC1HDAC2
SCHEMBL3582668 0.84 PPARA (0.43) PPARAPPARDFFAR4PPARGHRH3
SCHEMBL3578649 0.81 PPARD (0.40) PPARAPPARDHRH3
SCHEMBL3586169 0.81 PPARA (0.43) PPARAPPARDPPARGHDAC1HDAC2
SCHEMBL3568521 0.81 PPARA (0.41) PPARAPPARDPPARGHRH3
SCHEMBL13542095 0.79 PPARD (0.41) PPARAPPARDHDAC1HDAC2HDAC6
SCHEMBL13542098 0.77 PPARA (0.40) PPARAPPARDPPARGHRH3
SCHEMBL3574319 0.77 PPARD (0.49) PPARAPPARDFFAR4HRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100009969-A1 Fused Oxazoles & Thiazoles As Histamine H3- Receptor Ligands UCB PHARMA, S.A. (BE) 2010-01-14 US disclosed
US-20100009969-A1 Fused Oxazoles & Thiazoles As Histamine H3- Receptor Ligands UCB PHARMA, S.A. (BE) 2010-01-14 US disclosed
US-20100009969-A1 Fused Oxazoles & Thiazoles As Histamine H3- Receptor Ligands UCB PHARMA, S.A. (BE) 2010-01-14 US disclosed
EP-2049548-A1 FUSED OXAZOLES & THIAZOLES AS HISTAMINE H3- RECEPTOR LIGANDS UCB Pharma, S.A. (BE) 2009-04-22 EP disclosed
WO-2008012010-A1 FUSED OXAZOLES & THIAZOLES AS HISTAMINE H3- RECEPTOR LIGANDS UCB PHARMA, S.A. (BE) 2008-01-31 WO disclosed
WO-2008012010-A1 FUSED OXAZOLES & THIAZOLES AS HISTAMINE H3- RECEPTOR LIGANDS UCB PHARMA, S.A. (BE) 2008-01-31 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100009969-A1 Fused Oxazoles & Thiazoles As Histamine H3- Receptor Ligands HRH3, HRH4, HRH2 PPARA 1138/4885PPARD 1213/4885FFAR4 511/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.