Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 15/20 | 0.69 |
| ▸ | HSP90AA1 | P07900 | 7/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.55 |
| ▸ | CHUK | O15111 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3565500 | 0.82 | LRRK2 (0.61) | HSP90AB1HSP90AA1KCNH2 | |
| SCHEMBL22182265 | 0.82 | HSP90AB1 (0.56) | HSP90AB1HSP90AA1KCNH2CHUK | |
| SCHEMBL2568418 | 0.79 | HSP90AB1 (0.75) | HSP90AB1HSP90AA1KCNH2 | |
| SCHEMBL3572423 | 0.78 | LRRK2 (0.49) | HSP90AB1HSP90AA1CHUK | |
| SCHEMBL16177859 | 0.74 | LRRK2 (0.57) | HSP90AB1HSP90AA1CHUK | |
| SCHEMBL2566096 | 0.73 | HSP90AB1 (0.70) | HSP90AB1HSP90AA1KCNH2 | |
| SCHEMBL12161185 | 0.73 | HSP90AB1 (0.67) | HSP90AB1HSP90AA1KCNH2 | |
| SCHEMBL2563070 | 0.72 | HSP90AB1 (1.00) | HSP90AB1HSP90AA1KCNH2 | |
| SCHEMBL19266363 | 0.72 | CHUK (0.53) | HSP90AB1HSP90AA1CHUK | |
| SCHEMBL12161020 | 0.72 | KCNH2 (0.70) | HSP90AB1HSP90AA1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100010037-A1 | 1H-PYRROLO[2,3-B]PYRIDINE DERIVATIVES USEFUL AS HSP90 INHIBITORS | VERNALIS (R&D) LTD. (GB) | 2010-01-14 | — | — | US | claimed |
| US-20100010037-A1 | 1H-PYRROLO[2,3-B]PYRIDINE DERIVATIVES USEFUL AS HSP90 INHIBITORS | VERNALIS (R&D) LTD. (GB) | 2010-01-14 | — | — | US | disclosed |
| US-20100010037-A1 | 1H-PYRROLO[2,3-B]PYRIDINE DERIVATIVES USEFUL AS HSP90 INHIBITORS | VERNALIS (R&D) LTD. (GB) | 2010-01-14 | — | — | US | disclosed |
| US-20100010037-A1 | 1H-PYRROLO[2,3-B]PYRIDINE DERIVATIVES USEFUL AS HSP90 INHIBITORS | VERNALIS (R&D) LTD. (GB) | 2010-01-14 | — | — | US | disclosed |
| EP-2057155-A1 | 1H-PYRROLO[2,3-B]PYRIDINE DERIVATIVES USEFUL AS HSP90 INHIBITORS | Vernalis (R&D) Limited (GB) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008025947-A1 | 1H-PYRROLO[2,3-B]PYRIDINE DERIVATIVES USEFUL AS HSP90 INHIBITORS | VERNALIS (R & D) LTD. (GB) | 2008-03-06 | — | — | WO | disclosed |
| WO-2008025947-A1 | 1H-PYRROLO[2,3-B]PYRIDINE DERIVATIVES USEFUL AS HSP90 INHIBITORS | VERNALIS (R & D) LTD. (GB) | 2008-03-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100010037-A1 | 1H-PYRROLO[2,3-B]PYRIDINE DERIVATIVES USEFUL AS HSP90 INHIBITORS | HSP90AB1, HSP90AA1, HSP90AB2P | HSP90AB1 1/4885HSP90AA1 2/4885KCNH2 2054/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.