Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.47 |
| ▸ | TRPC7 | Q9HCX4 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | JAK1 | P23458 | 2/20 | 0.45 |
| ▸ | TYK2 | P29597 | 2/20 | 0.45 |
| ▸ | JAK3 | P52333 | 2/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | CLPP | Q16740 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3577202 | 1.00 | CYP1A2 (0.48) | CYP1A2CYP3A4CYP2C9CYP2C19TRPC3 | |
| SCHEMBL20028884 | 0.87 | JAK2 (0.47) | CYP2C19TSHRNPSR1JAK2JAK1 | |
| SCHEMBL3587612 | 0.85 | JAK2 (0.46) | CYP2C19TRPC3TRPC7NPSR1JAK2 | |
| SCHEMBL3587608 | 0.85 | JAK2 (0.46) | CYP2C19TRPC3TRPC7NPSR1JAK2 | |
| SCHEMBL29679550 | 0.83 | JAK2 (0.43) | CYP2C19TSHRLMNANPSR1JAK2 | |
| SCHEMBL20028877 | 0.83 | JAK2 (0.43) | CYP2C19TSHRLMNANPSR1JAK2 | |
| SCHEMBL3584728 | 0.79 | GRM5 (0.68) | CYP1A2CYP3A4CYP2C9CYP2C19TSHR | |
| SCHEMBL3584731 | 0.79 | GRM5 (0.68) | CYP1A2CYP3A4CYP2C9CYP2C19TSHR | |
| SCHEMBL3591829 | 0.78 | BCL9 (0.42) | TRPC3TRPC7NPSR1JAK2JAK1 | |
| SCHEMBL3591832 | 0.78 | BCL9 (0.42) | TRPC3TRPC7NPSR1JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2089386-B1 | OXAZOLE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMACEUTICALS SA (CH) | 2012-08-08 | — | — | EP | disclosed |
| US-20100081690-A1 | OXAZOLE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA SA (CH) | 2010-04-01 | — | — | US | disclosed |
| EP-2089386-A2 | OXAZOLE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX Pharma S.A. (CH) | 2009-08-19 | — | — | EP | disclosed |
| WO-2008056259-A2 | OXAZOLE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA S.A. (CH) | 2008-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100081690-A1 | OXAZOLE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | GRM5, GRM1, GRM2 | CYP1A2 3488/4885CYP3A4 3958/4885CYP2C9 3724/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.