Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.98 |
| ▸ | EGFR | P00533 | 13/20 | 0.98 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.80 |
| ▸ | AURKA | O14965 | 2/20 | 0.80 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.80 |
| ▸ | LCK | P06239 | 1/20 | 0.80 |
| ▸ | FYN | P06241 | 1/20 | 0.80 |
| ▸ | RET | P07949 | 1/20 | 0.80 |
| ▸ | MET | P08581 | 1/20 | 0.80 |
| ▸ | MAPT | P10636 | 1/20 | 0.80 |
| ▸ | SRC | P12931 | 1/20 | 0.80 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.80 |
| ▸ | LTK | P29376 | 1/20 | 0.80 |
| ▸ | TTK | P33981 | 1/20 | 0.80 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.80 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.80 |
| ▸ | BTK | Q06187 | 1/20 | 0.80 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.80 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29377224 | 0.89 | EGFR (1.00) | KDREGFRAURKBAURKAROCK2 | |
| SCHEMBL597105 | 0.89 | EGFR (1.00) | KDREGFRAURKBAURKAROCK2 | |
| SCHEMBL3530823 | 0.87 | AURKB (1.00) | KDREGFRAURKBAURKAROCK2 | |
| Anilinoquinazoline1 SCHEMBL30195580 | 0.87 | AURKB (1.00) | KDREGFRAURKBAURKAIRAK4 | |
| Anilinoquinazoline1 SCHEMBL1066538 | 0.87 | AURKB (1.00) | KDREGFRAURKBAURKAIRAK4 | |
| SCHEMBL13341789 | 0.86 | AURKB (0.84) | KDREGFRAURKBAURKAROCK2 | |
| SCHEMBL3534088 | 0.86 | AURKB (0.84) | KDREGFRAURKBAURKAROCK2 | |
| SCHEMBL3525693 | 0.86 | AURKB (0.84) | KDREGFRAURKBAURKAROCK2 | |
| Anilinoquinazoline1 SCHEMBL3968007 | 0.86 | AURKB (0.98) | KDREGFRAURKBAURKAIRAK4 | |
| SCHEMBL13341790 | 0.85 | AURKB (0.83) | KDREGFRAURKBAURKAROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709479-B1 | Quinazoline derivatives and their use as pharmaceuticals | ASTRAZENECA (SE) | 2010-05-04 | — | — | US | disclosed |
| EP-1218354-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021596-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |