Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 11/20 | 0.72 |
| ▸ | NR1H3 | Q13133 | 10/20 | 0.72 |
| ▸ | RXRA | P19793 | 9/20 | 0.72 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.52 |
| ▸ | CNR1 | P21554 | 5/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3579805 | 0.91 | NR1H2 (0.73) | NR1H2NR1H3RXRAPTGS2CNR1 | |
| SCHEMBL3577322 | 0.91 | NR1H2 (0.73) | NR1H2NR1H3RXRAPTGS2CNR1 | |
| SCHEMBL3578604 | 0.89 | NR1H2 (0.72) | NR1H2NR1H3RXRAPTGS2CNR1 | |
| SCHEMBL14621375 | 0.89 | NR1H2 (0.72) | NR1H2NR1H3RXRAPTGS2CNR1 | |
| SCHEMBL3580613 | 0.88 | NR1H2 (0.68) | NR1H2NR1H3RXRAPTGS2CNR1 | |
| SCHEMBL3227910 | 0.87 | NR1H2 (0.67) | NR1H2NR1H3RXRAPTGS2 | |
| SCHEMBL3583655 | 0.87 | NR1H2 (0.69) | NR1H2NR1H3RXRAPTGS2CNR1 | |
| SCHEMBL15988454 | 0.87 | NR1H2 (0.69) | NR1H2NR1H3RXRAPTGS2CNR1 | |
| SCHEMBL3583658 | 0.87 | NR1H2 (0.69) | NR1H2NR1H3RXRAPTGS2CNR1 | |
| SCHEMBL15459641 | 0.86 | NR1H2 (0.78) | NR1H2NR1H3RXRAPTGS2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9000022-B2 | Imidazole based LXR modulators | EXELIXIS PATENT COMPANY LLC (US) | 2015-04-07 | — | — | US | disclosed |
| EP-1910308-B1 | IMIDAZOLE BASED LXR MODULATORS | EXELIXIS PATENT CO LLC (US) | 2014-09-03 | — | — | EP | disclosed |
| US-20140038964-A1 | IMIDAZOLE BASED LXR MODULATORS | EXELIXIS PATENT COMPANY LLC (US) | 2014-02-06 | — | — | US | disclosed |
| US-8569352-B2 | Imidazole based LXR modulators | EXELIXIS PATENT COMPANY LLC (US) | 2013-10-29 | — | — | US | disclosed |
| US-20100075964-A1 | IMIDAZOLE BASED LXR MODULATORS | EXELIXIS, INC. (US) | 2010-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140038964-A1 | IMIDAZOLE BASED LXR MODULATORS | NR1H2, NR1H3, NR1H4 | NR1H2 1/4885NR1H3 2/4885RXRA 17/4885 |
| US-20100075964-A1 | IMIDAZOLE BASED LXR MODULATORS | NR1H2, NR1H3, NR1I2 | NR1H2 1/4885NR1H3 2/4885RXRA 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.